ArticleJournal of biomedical physics & engineering2021
Geant4 Modeling of Cellular Dosimetry of
Article in Journal of biomedical physics & engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The trial behind it
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe importance of cellular dosimetry in both diagnostic and radiation therapy is becoming increasingly recognized.
objectiveThis study aims to compare surviving fractions, which were predicted using Geant4 and contained three types of cancer cell lines exposed to MATERIAL AND
methodsIn this comparative study, Geant4 was used to simulate the transport of electrons emitted by
resultsFor single cell model, Geant4 S-values of nucleus-to-nucleus were consistent with values reported by Goddu et al. (ratio of S-values by analytical techniques vs. Geant4 = 0.811-0.975). Geant4 S-values of cytoplasm and cell surface to nucleus were relatively comparable to the reported values (ratio =0.914-1.21). For monolayer model, the values of S
conclusionGeant4 simulation with monolayer cell model showed the highest accuracy in predicting the SF of cancer cells exposed to homogeneous distribution of
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