Evidence map›Paper›PMID 34458157›Full record

ArticleFrontiers in cellular and infection microbiology2021

Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis.

Jie Chen, Hongfei Li, Sarah M Hird, Ming-Hui Chen, Wanli Xu, Kendra Maas, Xiaomei Cong

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie ChenSchool of Nursing, University of Connecticut, Storrs, CT, United States.
Hongfei LiDepartment of Statistics, University of Connecticut, Storrs, CT, United States.
Sarah M HirdDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, United States.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, CT, United States.
Wanli XuSchool of Nursing, University of Connecticut, Storrs, CT, United States.
Kendra MaasMicrobial Analysis, Resources, and Services (MARS), University of Connecticut, Storrs, CT, United States.
Xiaomei CongSchool of Nursing, University of Connecticut, Storrs, CT, United States.

Funding

Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm InfantsR01NR016928 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2017 to 2020
$2.5M
Early Life Experience Imprints Gut Microbiome in Preterm InfantsK23NR014674 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2013 to 2015
$396k
NINR NIH HHS K23 NR014674NINR NIH HHS R01 NR016928
6 · The paper itself

Abstract

Infant gut microbiota plays a vital role in immune response, mediates neurobehavioral development and health maintenance. Studies of twins' gut microbiota found that gut microbiota composition and diversity tend to be mature and stable with increasing postnatal age (PNA). Preterm infant gut microbiome shifts dramatically when they were staying in the neonatal intensive care unit (NICU). Compositions and shifting characteristics of gut microbiota among neonatal preterm twins and triplets during their early life are still unknown, which impedes a better understanding of the mechanism underpinning neurobehavioral development and precise intervention/health of preterm neonates. This longitudinal cohort study used a twins/triplets design to investigate the interaction of genetic (e.g., male

Indexed as

Gastrointestinal MicrobiomeSex CharacteristicsTwinsFemaleHumansInfantInfant, NewbornInfant, PrematureLongitudinal StudiesMalePhylogenygut microbiotaneonatal intensive care unitpreterm infantssextwins and triplets

Identifiers

PMID34458157
PMCPMC8387566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.