Evidence map›Paper›PMID 34458141›Full record

ArticleFrontiers in oncology2021

m

Congjun Zhang, Shuangyan Ou, Yuan Zhou, Pei Liu, Peiying Zhang, Ziqian Li, Ruocai Xu, Yuqiang Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Interplay of RNA mFASEB bioAdvances · 2026
    Article
  5. Review
  6. MedComm · 2026
    Article
  7. Review
  8. mFrontiers in cell and developmental biology · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Epitranscriptomic RNA mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Congjun ZhangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Shuangyan OuDepartment of Digestion and Urology, Hunan Tumor Hospital, Changsha, China.
Yuan ZhouDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
Pei LiuTumor Center, Hunan Chest Hospital, Changsha, China.
Peiying ZhangTumor Center, Hunan Chest Hospital, Changsha, China.
Ziqian LiTumor Center, Hunan Chest Hospital, Changsha, China.
Ruocai XuTumor Center, Hunan Chest Hospital, Changsha, China.
Yuqiang LiDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
Hunan Province Chest Hospital · CNCentral South University · CNFirst Affiliated Hospital of Anhui Medical University · CNHunan Cancer Hospital · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePancreatic cancer is one of the most lethal human malignancies. Gemcitabine is widely used to treat pancreatic cancer, and the resistance to chemotherapy is the major difficulty in treating the disease.

methodsThe mRNA and protein level of m

resultsWe found that gemcitabine treatment significantly increased the expression of m

conclusionOur study suggested that METTL14 is a potential target for chemotherapy resistance in pancreatic cancer.

Indexed as

chemotherapyMETTL14N6-methyladenosinep65pancreatic cancer

Identifiers

PMID34458141
PMCPMC8385558
OpenAlexW3192429329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.