Evidence map›Paper›PMID 34457433›Full record

ArticleBiomedical optics express2021

Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits.

Eric M Moult, Yingying Shi, Qinqin Zhang, Liang Wang, Rahul Mazumder, Siyu Chen, Zhongdi Chu, William Feuer, Nadia K Waheed, Giovanni Gregori and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Geographic atrophy: Understanding the relationship between structure and function.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eric M MoultDepartment of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.
Yingying ShiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Qinqin ZhangDepartment of Bioengineering, University of Washington, Seattle, WA 98104, USA.
Liang WangDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Rahul MazumderSloan School of Management, Operations Research Center and Center for Statistics, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.
Siyu ChenDepartment of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.
Zhongdi ChuDepartment of Bioengineering, University of Washington, Seattle, WA 98104, USA.ORCID https://orcid.org/0000-0001-7430-5032
William FeuerDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Boston, MA 02111, USA.
Giovanni GregoriDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, WA 98104, USA.ORCID https://orcid.org/0000-0001-5169-8822
Philip J RosenfeldDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
James G FujimotoDepartment of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.

Funding

Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
NEI NIH HHS R01 EY011289
6 · The paper itself

Abstract

The purpose of this study is to quantitatively assess correlations between local geographic atrophy (GA) growth rates and local optical coherence tomography angiography (OCTA)-measured choriocapillaris (CC) flow deficits. Thirty-eight eyes from 27 patients with GA secondary to age-related macular degeneration (AMD) were imaged with a commercial 1050 nm swept-source OCTA instrument at 3 visits, each separated by ∼6 months. Pearson correlations were computed between local GA growth rates, estimated using a biophysical GA growth model, and local OCTA CC flow deficit percentages measured along the GA margins of the baseline visits. The p-values associated with the null hypothesis of no Pearson correlation were estimated using a Monte Carlo permutation scheme that incorporates the effects of spatial autocorrelation. The null hypothesis (Pearson's

Identifiers

PMID34457433
PMCPMC8367222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.