ArticleBiomedical optics express2021
Identification and quantification of fibrotic areas in the human retina using polarization-sensitive OCT.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Imaging and functional correlates of fibrosis in neovascular age-related macular degeneration: a systematic review.Frontiers in ophthalmology · 2026Pooled it
- Multimodal Imaging of Dual BEST1/EFEMP1-Associated Hereditary Macular Disease.Journal of clinical medicine · 2026Article
- Imaging biomarkers and artificial intelligence for diagnosis, prediction, and therapy of macular fibrosis in age-related macular degeneration: Narrative review and future directions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- JR5558 mice are a reliable model to investigate subretinal fibrosis.Scientific reports · 2024Article
- Structure-Function Correlation of Retinal Fibrosis in Eyes with Neovascular Age-Related Macular Degeneration.Journal of clinical medicine · 2024Article
- Automated inter-device 3D OCT image registration using deep learning and retinal layer segmentation.Biomedical optics express · 2023Article
- Characteristics of Henle's fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography.Biomedical optics express · 2023Article
- Local axis orientation mapped by polarization sensitive optical coherence tomography provides a unique contrast to identify caries lesions in enamel.Biomedical optics express · 2022Article
- Intraoral optical coherence tomography and angiography combined with autofluorescence for dental assessment.Biomedical optics express · 2022Article
- Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration.Scientific reports · 2022Observational
- Morphologic and Microvascular Differences Between Macular Neovascularization With and Without Subretinal Fibrosis.Translational vision science & technology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subretinal fibrosis is one of the most prevalent causes of blindness in the elderly population, but a true gold standard to objectively diagnose fibrosis is still lacking. Since fibrotic tissue is birefringent, it can be detected by polarization-sensitive optical coherence tomography (PS-OCT). We present a new algorithm to automatically detect, segment, and quantify fibrotic lesions within 3D data sets recorded by PS-OCT. The algorithm first compensates for the birefringence of anterior ocular tissues and then uses the uniformity of the birefringent optic axis as an indicator to identify fibrotic tissue, which is then segmented and quantified. The algorithm was applied to 3D volumes recorded in 57 eyes of 57 patients with neovascular age-related macular degeneration using a spectral domain PS-OCT system. The results of fibrosis detection were compared to the clinical diagnosis based on color fundus photography (CFP), and the precision of fibrotic area measurement was assessed by three repeated measurements in a sub-set of 15 eyes. The average standard deviation of the fibrotic area obtained in eyes with a lesion area > 0.7 mm
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Registered trials
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