Evidence map›Paper›PMID 34457416›Full record

ArticleBiomedical optics express2021

Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy.

Andreas Wartak, Alfred K Kelada, Paola A Leon Alarcon, Ara L Bablouzian, Osman O Ahsen, Abigail L Gregg, Yuxiao Wei, Keval Bollavaram, Conor J Sheil, Edward Farewell and 6 more

Abstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andreas WartakWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-0825-3187
Alfred K KeladaWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Paola A Leon AlarconWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Ara L BablouzianWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Osman O AhsenWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Abigail L GreggWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Yuxiao WeiWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Keval BollavaramWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Conor J SheilWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-9077-4573
Edward FarewellWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Schuyler VanTolWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Rachel SmithWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Patricia GrahmannWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Aaron R BaillargeonWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Joseph A GardeckiWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OCT tethered capsule endomicroscopy (TCE) is an emerging noninvasive diagnostic imaging technology for gastrointestinal (GI) tract disorders. OCT measures tissue reflectivity that provides morphologic image contrast, and thus is incapable of ascertaining molecular information that can be useful for improving diagnostic accuracy. Here, we introduce an extension to OCT TCE that includes a fluorescence (FL) imaging channel for attaining complementary, co-registered molecular contrast. We present the development of an OCT-FL TCE capsule and a portable, plug-and-play OCT-FL imaging system. The technology is validated in phantom experiments and feasibility is demonstrated in a methylene blue (MB)-stained swine esophageal injury model,

Identifiers

PMID34457416
PMCPMC8367220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.