ArticleBiomedical optics express2021
Comparison of photoacoustic imaging and histopathological examination in determining the dimensions of 52 human melanomas and nevi
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review.Journal of biomedical optics · 2024Pooled it
- Personalized digital pipeline for basal cell carcinoma delineation using hyperspectral imaging.Biomedical optics express · 2026Article
- Photoacoustic Imaging in Immune-Mediated Inflammatory Skin Diseases: Diagnostic and Therapeutic Applications.Diagnostics (Basel, Switzerland) · 2026Review
- Label-free streamlined photoacoustic image guidance facilitates NIR-II photoablation in models of melanoma lung metastases.The Journal of clinical investigation · 2026Article
- Multispectral Laser-Scanning Photoacoustic Microscopy With SRS-Generated Wavelengths for Skin Chromophore Characterization.Journal of biophotonics · 2026Article
- Advancing non-invasive melanoma diagnostics with deep learning and multispectral photoacoustic imaging.Photoacoustics · 2025Article
- Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging.Photoacoustics · 2025Article
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Mapping the architecture of the temporal artery with photoacoustic imaging for diagnosing giant cell arteritis.Photoacoustics · 2022Article
- The emerging role of photoacoustic imaging in clinical oncology.Nature reviews. Clinical oncology · 2022Review
- Melanin concentration maps by label-free super-resolution photo-thermal imaging on melanoma biopsies.Biomedical optics express · 2022Article
- Photoacoustic imaging of periorbital skin cancerBiomedical optics express · 2022Article
- Translational Photoacoustic Imaging for Disease Diagnosis, Monitoring, and Surgical Guidance: introduction to the feature issue.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical excision followed by histopathological examination is the gold standard for the diagnosis and staging of melanoma. Reoperations and unnecessary removal of healthy tissue could be reduced if non-invasive imaging techniques were available for presurgical tumor delineation. However, no technique has gained widespread clinical use to date due to shallow imaging depth or the absence of functional imaging capability. Photoacoustic (PA) imaging is a novel technology that combines the strengths of optical and ultrasound imaging to reveal the molecular composition of tissue at high resolution. Encouraging results have been obtained from previous animal and human studies on melanoma, but there is still a lack of clinical data. This is the largest study of its kind to date, including 52 melanomas and nevi. 3D multiwavelength PA scanning was performed ex vivo, using 59 excitation wavelengths from 680 nm to 970 nm. Spectral unmixing over this broad wavelength range, accounting for the absorption of several tissue chromophores, provided excellent contrast between healthy tissue and tumor. Combining the results of spectral analysis with spatially resolved information provided a map of the tumor borders in greater detail than previously reported. The tumor dimensions determined with PA imaging were strongly correlated with those determined by histopathological examination for both melanomas and nevi.
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Registered trials
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