ArticleBiomedical optics express2021
Full circumferential morphological analysis of Schlemm's canal in human eyes using megahertz swept source OCT.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Machine-Learning-Based Automated Schlemm's Canal Volumetric Segmentation for Optical Coherence Tomography.Chemical & biomedical imaging · 2026Article
- Circumferential multi-contrast mapping of the aqueous outflow pathway in human eyes facilitated by circular-scan optical coherence tomography angiography.Biomedical optics express · 2026Article
- Imaging fine structures of the human trabecular meshworkBiomedical optics express · 2023Article
- Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography.Scientific reports · 2023Article
- Article
- Advancements in high-resolution imaging of the iridocorneal angle.Frontiers in ophthalmology · 2023Review
- Characterization of the human iridocorneal angleBiomedical optics express · 2022Article
- Evaluation of different OCT systems in quantitative imaging of human Schlemm's canal.Scientific reports · 2022Article
- Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery.Frontiers in medicine · 2022Article
- Open-source deep learning-based automatic segmentation of mouse Schlemm's canal in optical coherence tomography images.Experimental eye research · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed full circumferential imaging of the Schlemm's canal (SC) of two human eyes using a Fourier domain mode-lock laser (FDML) based 1.66-MHz SS-OCT prototype at 1060 nm. Eight volumes with overlapping margins were acquired around the limbal area with customized raster scanning patterns designed to fully cover the SC while minimizing motion artifacts. The SC was segmented from the volumes using a semi-automated active contour segmentation algorithm, whose mean dice similarity coefficient was 0.76 compared to the manual segmentation results. We also reconstructed three-dimensional (3D) renderings of the 360° SC by stitching the segmented SCs from the volumetric datasets. Quantitative metrics of the full circumferential SC were provided, including the mean and standard deviation (SD) of the cross-sectional area (CSA), the maximum CSA, the minimum and maximum SC opening width, and the number of collector channels (CC) stemming from the SC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.