ReviewWorld journal of gastrointestinal oncology2021
Young-onset colorectal cancer: A review.
Review in World journal of gastrointestinal oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- The histological and molecular characteristics of early-onset colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Direct medical costs of young-onset colorectal cancer: a worldwide systematic review.BMC health services research · 2022Pooled it
- The rapid surge of colorectal cancer in children and young adults: a 22-year analysis of the CDC WONDER database.Proceedings (Baylor University. Medical Center) · 2026Article
- Evaluating Quality, Guideline Accuracy, and Racial/Ethnic Representation of YouTube Videos on Colon Cancer Screening.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Association between Oxidative Balance Score and Colorectal Cancer: Insights from NHANES 1999-2018.Journal of Cancer · 2026Article
- Demonstrating trends for early colorectal cancer incidence: a retrospective analysis of patients in Northwest Ohio.Frontiers in oncology · 2026Article
- Imaging of young-onset colorectal cancer: what the radiologist needs to know.Abdominal radiology (New York) · 2025Review
- Disparities in Colorectal Cancer Mortality and Survival Trends Among Hispanics Living in Puerto Rico (2000-2021): A Comparison Between Early-Onset and Average-Onset Disease.Life (Basel, Switzerland) · 2025Article
- Don't take this lying down: an urgent wakeup call: the weight of diet and lifestyle in the young-onset colorectal cancer surge.ANZ journal of surgery · 2025Article
- Unraveling Early Onset Disparities and Determinants: An Analysis of Colorectal Cancer Outcomes and Trends in Texas.Cureus · 2025Article
- Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis.World journal of gastrointestinal oncology · 2025Article
- Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study.World journal of gastrointestinal oncology · 2025Article
- Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner.Scientific reports · 2025Article
- Short-Term Outcomes of Laparoscopic Rectal Cancer Surgery at a High-Volume Center in Peshawar, Pakistan.Cureus · 2025Article
- Clinicopathological and radiological characteristics and prediction of survival in colon cancer.World journal of gastrointestinal oncology · 2025Article
- E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration.Journal of experimental & clinical cancer research : CR · 2025Article
- Sex and age-related differences in one-, three-, and five-year survival for early-onset colorectal cancer in Georgia.American journal of cancer research · 2025Article
- Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study.Therapeutic advances in medical oncology · 2025Article
- WNT and TGF-Beta Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Populations.Cancers · 2024Review
- Age as a Predictor of Overall Survival in Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the general decrease in overall incidence of colorectal cancer since the early 1990s, the incidence of colorectal cancer in patients less than 50 years old has nearly doubled. A systematic review was performed using the PubMed database (2011-2020) and Cochrane Database of Systematic Reviews (2011-2021) to identify studies (published in English) evaluating epidemiologic, clinical, hereditary, and molecular features; as well as evaluation, management, and prognosis of young-onset colorectal cancer patients. Our search yielded a total of 3401 articles, after applying our inclusion criteria. We fully reviewed 94 full-length studies. This systematic review demonstrates the increasing incidence of young-onset colorectal cancer and highlights the importance of being hypervigilant for the differential diagnosis colorectal cancer when evaluating a young adult who presents with gastrointestinal symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.