Evidence map›Paper›PMID 34456996›Full record

ReviewNeural plasticity2021

Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI.

Jinhuan Zhang, Chunjian Lu, Xiaoxiong Wu, Dehui Nie, Haibo Yu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural plasticity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 12 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 12 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  16. Mechanisms of acupuncture-regulated cortical plasticity after stroke based on TMS-EEG-MEP integration.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jinhuan ZhangThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China.ORCID 0000-0002-8634-0633
Chunjian LuThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China.
Xiaoxiong WuThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China.
Dehui NieThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China.
Haibo YuThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China.ORCID 0000-0003-3100-0786
Guangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation. Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic resonance imaging (MRI), as a noninvasive, high anatomical resolution technique, has been employed to investigate neuroplasticity on acupuncture in stroke patients from a system level. However, there is no review on the mechanism of acupuncture treatment for stroke based on MRI. Therefore, we aim to summarize the current evidence about this aspect and provide useful information for future research. After searching PubMed, Web of Science, and Embase databases, 24 human and five animal studies were identified. This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. We found that acupuncture reorganizes not only motor-related network, including primary motor cortex (M1), premotor cortex, supplementary motor area (SMA), frontoparietal network (LFPN and RFPN), and sensorimotor network (SMN), as well as default mode network (aDMN and pDMN), but also language-related brain areas including inferior frontal gyrus frontal, temporal, parietal, and occipital lobes, as well as cognition-related brain regions. In addition, acupuncture therapy can modulate the function and structural plasticity of post-stroke, which may be linked to the mechanism effect of acupuncture.

Indexed as

Acupuncture TherapyBrainHumansMagnetic Resonance ImagingNeuronal PlasticityStrokeStroke RehabilitationTreatment Outcome

Identifiers

PMID34456996
PMCPMC8397547
OpenAlexW3194839745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.