Evidence map›Paper›PMID 34456919›Full record

ReviewFrontiers in immunology2021

Mouse Models of Germinal Center Derived B-Cell Lymphomas.

Stefanie N Meyer, Sanjay Koul, Laura Pasqualucci

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Mouse models of diffuse large B cell lymphoma.Frontiers in immunology · 2023
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefanie N MeyerInstitute for Cancer Genetics, Columbia University, New York, NY, United States.
Sanjay KoulDepartment of Biological Sciences & Geology, Queensborough Community College (City University of New York), Bayside, NY, United States.
Laura PasqualucciInstitute for Cancer Genetics, Columbia University, New York, NY, United States.

Funding

Role of MLL2 Gene Inactivation in B cell Non Hodgkin LymphomaR01CA172492 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PASQUALUCCI, LAURA · 2013 to 2022
$3.6M
Role of CREBBP missense mutations in lymphomagenesisR01CA260176 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Riccardo Dalla-Favera · 2022 to 2026
$2.3M
NCI NIH HHS R01 CA172492NCI NIH HHS R01 CA260176
6 · The paper itself

Abstract

Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells -the origin of most B-cell lymphomas- will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors

Indexed as

Disease Models, AnimalGenetic EngineeringAdoptive TransferAnimalsGenes, mycGerminal CenterHistonesHumansLymphoma, B-CellMiceMutationTranslocation, GeneticTumor MicroenvironmentHistonesgeneticsgerminal centerlymphomamouse modelstransgenic

Identifiers

PMID34456919
PMCPMC8387591

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.