Evidence map›Paper›PMID 34456907›Full record

ArticleFrontiers in immunology2021

CMV Infection Is Directly Related to the Inflammatory Status in Chronic Heart Failure Patients.

Alejandra García-Torre, Eva Bueno-García, Rocío López-Martínez, Beatriz Rioseras, Beatriz Díaz-Molina, José Luis Lambert, Covadonga Quirós, Sara Alonso-Álvarez, Rebeca Alonso-Arias, Marco A Moro-García

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. The immune response to human cytomegalovirus: impact of age, co-morbidities and the significance of anti-viral activity assessment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Immunosenescence: an unexplored role in glomerulonephritis.Clinical & translational immunology · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alejandra García-TorreImmunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Eva Bueno-GarcíaImmunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Rocío López-MartínezImmunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Beatriz RioserasImmunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Beatriz Díaz-MolinaDepartment of Cardiac Pathology, Health Research Institute of the Principality of Asturias - ISPA, Oviedo, Spain.
José Luis LambertDepartment of Cardiac Pathology, Health Research Institute of the Principality of Asturias - ISPA, Oviedo, Spain.
Covadonga QuirósLaboratory Medicine Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Sara Alonso-ÁlvarezDepartment of Cardiac Pathology, Health Research Institute of the Principality of Asturias - ISPA, Oviedo, Spain.
Rebeca Alonso-AriasImmunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Marco A Moro-GarcíaDepartment of Cardiac Pathology, Health Research Institute of the Principality of Asturias - ISPA, Oviedo, Spain.
Hospital Universitario Central de Asturias · ESGobierno del Principado de Asturias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High levels of inflammation play an important role in chronic heart failure (CHF). Patients with CHF have elevated levels of pro-inflammatory cytokines circulating systemically, mainly TNF and IL-6. However, there are almost no studies that relate these levels to the functional status of patients in CHF, much less to their CMV serostatus. In this study, patients with CHF (n=40; age=54.9 ± 6.3; New York Heart Association functional classification (NYHA, I-III) and healthy controls (n=40; age=53.5 ± 7.1) were analyzed. The serum concentrations of nine pro- and anti-inflammatory cytokines were measured by Luminex

Indexed as

Antibodies, ViralBiomarkersCase-Control StudiesCD28 AntigensCD4-Positive T-LymphocytesChronic DiseaseCytokinesCytomegalovirusCytomegalovirus InfectionsFemaleHeart FailureHost-Pathogen InteractionsHumansInflammationInflammation MediatorsMaleAntibodies, ViralBiomarkersCD28 AntigensCytokinesInflammation MediatorsCHFCMVIL-6immunosenescenceinflammationT-lymphocyteTNF

Identifiers

PMID34456907
PMCPMC8387659
OpenAlexW3194120062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.