Evidence map›Paper›PMID 34456753›Full record

ArticleFrontiers in physiology2021

Mouse Model of Loeys-Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling.

Satoru Yamada, Kenichiro Tsushima, Masaki Kinoshita, Hiromi Sakashita, Tetsuhiro Kajikawa, Chiharu Fujihara, Hang Yuan, Shigeki Suzuki, Takayuki Morisaki, Shinya Murakami

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. The genetics of hyper IgE syndromes.Frontiers in immunology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Satoru YamadaDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Kenichiro TsushimaDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Masaki KinoshitaDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Hiromi SakashitaDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Tetsuhiro KajikawaDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Chiharu FujiharaDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Hang YuanDepartment of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Shigeki SuzukiDepartment of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Takayuki MorisakiDivision of Molecular Pathology, Laboratory of Genome Technology IMSUT Hospital, Department of Internal Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Bunkyo, Japan.
Shinya MurakamiDepartment of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Osaka University · JPTohoku University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loeys-Dietz syndrome (LDS) is a syndromic connective tissue disorder caused by a heterozygous missense mutation in genes that encode transforming growth factor (TGF)-β receptor (

Indexed as

extracelluar matixknock-in miceperiodontal ligamentperiodontitisTGF-beta

Identifiers

PMID34456753
PMCPMC8385443
OpenAlexW3194339686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.