Evidence map›Paper›PMID 34456639›Full record

ArticleMultiscale modeling & simulation : a SIAM interdisciplinary journal2020

Computational model of electrode-induced microenvironmental effects on pH measurements near a cell membrane.

D Calvetti, J Prezioso, R Occhipinti, W F Boron, E Somersalo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiscale modeling & simulation : a SIAM interdisciplinary journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Mechanism of COThe Journal of physiology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D CalvettiDepartment of Mathematics, Applied Mathematics and Statistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106.
J PreziosoDepartment of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106.
R OcchipintiDepartment of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106.
W F BoronDepartment of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106.
E SomersaloDepartment of Mathematics, Applied Mathematics and Statistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106.
Case Western Reserve University · US

Funding

Multi-scale modeling of gas transport through channels in living cellsU01GM111251 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F, SOMERSALO, ERKKI JAAKKO · 2015 to 2019
$2.9M
Role of RPTP-gamma in sensing and transducing acid-base disturbances in the renal proximal tubuleR01DK113197 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F · 2017 to 2020
$2.0M
Acid secretion and intracellular pH regulation in proximal-tubule cellsK01DK107787 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI OCCHIPINTI, ROSSANA · 2015 to 2019
$541k
NIDDK NIH HHS K01 DK107787NIDDK NIH HHS R01 DK113197NIGMS NIH HHS U01 GM111251
6 · The paper itself

Abstract

The mechanism of gas transport across cell membranes remains a topic of considerable interest, particularly regarding the extent to which lipids vs. specific membrane proteins provide conduction pathways. Studies of transmembrane (CO

Indexed as

anisotropyGas channelsmulti-scale modelingreaction-diffusion

Identifiers

PMID34456639
PMCPMC8388135
OpenAlexW3031370251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.