Evidence map›Paper›PMID 34456580›Full record

ArticleJournal of inflammation research2021

Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk.

Abigail C Burr, Jalene V Velazquez, Arzu Ulu, Rohan Kamath, Sang Yong Kim, Amanpreet K Bilg, Aileen Najera, Iman Sultan, Jon K Botthoff, Emma Aronson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. A two-sample Mendelian randomization study of the causal relationship between respiratory diseases, gastric cancer risk, and Helicobacter pylori infection.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Influence of Rural Environmental Factors in Asthma.Immunology and allergy clinics of North America · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Abigail C Burr *Division of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Jalene V Velazquez *Division of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Arzu UluDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Rohan KamathDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Sang Yong KimDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Amanpreet K BilgDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Aileen NajeraDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Iman SultanDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Jon K BotthoffCenter for Conservation Biology, University of California Riverside, Riverside, CA, 92521, USA.
Emma AronsonDepartment of Plant Pathology and Microbiology, University of California Riverside, Riverside, CA, 92521, USA.
Meera G NairDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
Tara M NordgrenDivision of Biomedical Sciences, University of California Riverside, Riverside, CA, 92521, USA.
University of California, Riverside · US

Funding

RELMalpha-expressing macrophages mediate host disease tolerance in mucosal infectionR01AI153195 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI NAIR, MEERA GOH · 2020 to 2024
$3.5M
The role of omega-3 fatty acids and bioactive lipid signaling in airway inflammation and resolution following organic dust exposuresR00ES025819 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI NORDGREN, TARA M · 2017 to 2019
$747k
NIAID NIH HHS R01 AI153195NIEHS NIH HHS R00 ES025819
6 · The paper itself

Abstract

purposeThe Salton Sea, California's largest lake, is designated as an agricultural drainage reservoir. In recent years, the lake has experienced shrinkage due to reduced water sources, increasing levels of aerosolized dusts in surrounding regions. Communities surrounding the Salton Sea have increased asthma prevalence versus the rest of California; however, a connection between dust inhalation and lung health impacts has not been defined.

methodsWe used an established intranasal dust exposure murine model to study the lung inflammatory response following single or repetitive (7-day) exposure to extracts of dusts collected in regions surrounding the Salton Sea (SSDE), complemented with in vitro investigations assessing SSDE impacts on the airway epithelium.

resultsIn these investigations, single or repetitive SSDE exposure induced significant lung inflammatory cytokine release concomitant with neutrophil influx. Repetitive SSDE exposure led to significant lung eosinophil recruitment and altered expression of genes associated with allergen-mediated immune response, including Clec4e. SSDE treatment of human bronchial epithelial cells (BEAS-2B) induced inflammatory cytokine production at 5- and 24-hours post-treatment. When BEAS-2B were exposed to protease activity-depleted SSDE (PDSSDE) or treated with SSDE in the context of protease-activated receptor-1 and -2 antagonism, inflammatory cytokine release was decreased. Furthermore, repetitive exposure to PDSSDE led to decreased neutrophil and eosinophilic influx and IL-6 release in mice compared to SSDE-challenged mice.

conclusionThese investigations demonstrate potent lung inflammatory responses and tissue remodeling in response to SSDE, in part due to environmental proteases found within the dusts. These studies provide the first evidence supporting a link between environmental dust exposure, protease-mediated immune activation, and respiratory disease in the Salton Sea region.

Indexed as

asthmadust exposurelung inflammationprotease-activated receptorsproteasesSalton Sea

Identifiers

PMID34456580
PMCPMC8387588
OpenAlexW3195835732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.