Evidence map›Paper›PMID 34456531›Full record

ArticleMacromolecular chemistry and physics2021

Solute Transport Dependence on 3D Geometry of Hydrogel Networks.

Nathan R Richbourg, Akhila Ravikumar, Nicholas A Peppas

Open access · greenAbstract read
In one paragraph

Article in Macromolecular chemistry and physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Photochemical Control of Network Topology in PEG Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2024
    Article
  6. Review
  7. Diffusion-Based 3D Bioprinting Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Hyaluronic Acid-PEG-Based Diels-AlderBiomacromolecules · 2022
    Article
  12. Review
  13. Review
  14. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
  15. Review
  16. Article
  17. Frontiers in bioengineering and biotechnology · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nathan R RichbourgDepartment of Biomedical Engineering, University of Texas, Austin, TX 78712, USA.
Akhila RavikumarDepartment of Biomedical Engineering, University of Texas, Austin, TX 78712, USA.
Nicholas A PeppasDepartment of Biomedical Engineering, University of Texas, Austin, TX 78712, USA.
The University of Texas at Austin · USAustin College · US

Funding

Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndromeR01EB022025 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V., PEPPAS, NICHOLAS A · 2016 to 2019
$1.5M
NIBIB NIH HHS R01 EB022025
6 · The paper itself

Abstract

Hydrogels are used in drug delivery applications, chromatography, and tissue engineering to control the rate of solute transport based on solute size and hydrogel-solute affinity. Ongoing modeling efforts to quantify the relationship between hydrogel properties, solute properties, and solute transport contribute toward an increasingly efficient hydrogel design process and provide fundamental insight into the mechanisms relating hydrogel structure and function. However, here we clarify previous conclusions regarding the use of mesh size in hydrogel transport models. We use 3D geometry and hydrogel network visualizations to show that mesh size and junction functionality both contribute to the mesh radius, which determines whether a solute can diffuse within a hydrogel. Using mesh radius instead of mesh size to model solute transport in hydrogels will correct junction functionality-dependent modeling errors, improving hydrogel design predictions and clarifying mechanisms of solute transport in hydrogels.

Indexed as

3D modelingHydrogelmesh sizepolymer network structuresolute diffusivity

Identifiers

PMID34456531
PMCPMC8389770
OpenAlexW3185267964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.