Evidence map›Paper›PMID 34455897›Full record

ArticleJournal of immunotoxicology2021

Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice.

Colleen T O'Dell, Lisbeth A Boule, Jacques Robert, Steve N Georas, Sophia Eliseeva, B Paige Lawrence

Open access · goldAbstract read
In one paragraph

Article in Journal of immunotoxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Colleen T O'DellDepartment of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Lisbeth A BouleDepartment of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Jacques RobertDepartment of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Steve N GeorasDepartment of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Sophia EliseevaDepartment of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
B Paige LawrenceDepartment of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
University of Rochester · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHT32HL066988 · NHLBI · UNIVERSITY OF ROCHESTER · PI GEORAS, STEVE N, O'REILLY, MICHAEL A · 2001 to 2021
$8.1M
A Xenopus Laevis Research Resource for ImmunologyR24AI059830 · NIAID · UNIVERSITY OF ROCHESTER · PI JACQUES Robert · 2004 to 2026
$7.7M
TCDD EFFECT ON T LYMPHOCYTE DIFFERENTIATIONR01ES004862 · NIEHS · UNIVERSITY OF ROCHESTER · PI LAWRENCE, B PAIGE · 1990 to 2020
$6.5M
Transgenerational exposures as modifiers of host defense against infectionR01ES023260 · NIEHS · UNIVERSITY OF ROCHESTER · PI LAWRENCE, B PAIGE · 2013 to 2017
$3.0M
Human Immunotoxicity of Developmental PCB ExposureR01ES030300 · NIEHS · UNIVERSITY OF ROCHESTER · PI JUSKO, TODD, LAWRENCE, B PAIGE · 2019 to 2024
$2.7M
Assembly of the mycobacterial cell wallR01AI073772 · NIAID · UNIVERSITY OF ROCHESTER · PI PAVELKA, MARTIN S. · 2008 to 2012
$1.9M
Long-term effects of developmental exposure to a mixture of thyroid disruptors associated with hydrofracking on T cell development and antimicrobial immunityR21ES030690 · NIEHS · UNIVERSITY OF ROCHESTER · PI ROBERT, JACQUES · 2020 to 2021
$424k
NHLBI NIH HHS T32 HL066988NIAID NIH HHS R01 AI073772NIAID NIH HHS R24 AI059830NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES004862NIEHS NIH HHS R01 ES023260NIEHS NIH HHS R01 ES030300NIEHS NIH HHS R21 ES030690NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

The prevalence of unconventional oil and gas (UOG) operations raises concerns regarding the potential for adverse health outcomes following exposure to water tainted by mixtures of UOG associated chemicals. The potential effects that exposure to complex chemical mixtures has on the immune system have yet to be fully evaluated. In this study, effects on the immune system of adult mice exposed to a mixture of 23 chemicals that have been associated with water near active UOG operations were investigated. Female and male mice were exposed to the mixture

Indexed as

Endocrine DisruptorsWater Pollutants, ChemicalAnimalsComplex MixturesFemaleImmunityMaleMiceComplex MixturesEndocrine DisruptorsWater Pollutants, Chemicalallergyautoimmunehydraulic fracturingimmunotoxicityinfluenzaWater pollutants

Identifiers

PMID34455897
PMCPMC8782265
OpenAlexW3197739353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.