ArticleCirculation2021
Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation.
Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02304276 (18F-Fluoride Assessment of Aortic Bioprosthesis Durability and Outcome), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
18F-Fluoride Assessment of Aortic Bioprosthesis Durability and Outcome
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Neosinus and Valve Thrombosis After Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2026Pooled it
- Viscoelastic Properties of Porcine Pericardium Under Biaxial Tensile Creep and Stress Relaxation: Application for Novel Aortic Valve Bioprosthesis Design.Bioengineering (Basel, Switzerland) · 2026Article
- Association of SGLT2 Inhibitors with Mortality and Bioprosthesis Valve Failure After TAVR: A Propensity-Matched Cohort Study.Journal of clinical medicine · 2025Article
- Plasma-Derived Extracellular Vesicle-Propagated microRNA From Aortic Stenosis Patients Render Pro-Calcifying Effects on Valve Interstitial Cells.JACC. Basic to translational science · 2025Article
- Subclinical Leaflet Thrombosis and Subclinical Aortic Valve Complex Thrombosis in TAVR.JACC. Advances · 2025Review
- Emerging Applications of Positron Emission Tomography in Coronary Artery Disease.Journal of personalized medicine · 2025Review
- Mechano-electrical-fluid interaction left-ventricle model for numerical evaluation of aortic valve hemodynamics.Frontiers in bioengineering and biotechnology · 2025Article
- Imaging small dynamic lesions using positron emission tomography and computed tomography: anEuropean heart journal. Imaging methods and practice · 2025Article
- Bioprosthetic Aortic Valve Degeneration After TAVR and SAVR: Incidence, Diagnosis, Predictors, and Management.Journal of cardiovascular development and disease · 2024Review
- Sex differences in coronary atherosclerotic plaque activity usingEuropean journal of nuclear medicine and molecular imaging · 2024Article
- Temporal changes in biomarker levels and their association with the early degeneration stage of transcatheter aortic valves inPostepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Sex Differences in Aortic Stenosis: From the Pathophysiology to the Intervention, Current Challenges, and Future Perspectives.Journal of clinical medicine · 2024Review
- Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway.JACC. Basic to translational science · 2024Article
- CT imaging post-TAVI: Murphy's first law in action-preparing to recognize the unexpected.Insights into imaging · 2024Review
- Machine learning for prediction of all-cause mortality after transcatheter aortic valve implantation.European heart journal. Quality of care & clinical outcomes · 2023Article
- Early Biological Valve Failure: Structural Valve Degeneration, Thrombosis, or Endocarditis?Journal of clinical medicine · 2023Review
- Contemporary issues and lifetime management in patients underwent transcatheter aortic valve replacement.Cardiovascular intervention and therapeutics · 2023Review
- Latent Coronary Plaque Morphology From Computed Tomography Angiography, Molecular Disease Activity on Positron Emission Tomography, and Clinical Outcomes.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Serum lipoprotein(a) and bioprosthetic aortic valve degeneration.European heart journal. Cardiovascular Imaging · 2023Article
- Imaging of Bioprosthetic Valve Dysfunction after Transcatheter Aortic Valve Implantation.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
- Commented on by
Authors and funding
23 authors at 9 institutions in 5 countries.
Jacek Kwiecinski *Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.).ORCID 0000-0001-8202-6359
Evangelos Tzolos *Centre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.ORCID 0000-0003-0038-043X
Timothy R G Cartlidge *Centre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.
Alexander FletcherCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.ORCID 0000-0001-9984-8391
Mhairi K DorisCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.
Rong BingCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.
Jason M TarkinDivision of Cardiovascular Medicine, University of Cambridge, UK (J.M.T., J.H.F.R.).ORCID 0000-0002-9132-120X
Michael A SeidmanORCID 0000-0002-9594-827X
Gaurav S GulsinDepartment of Radiology, Centre for Cardiovascular Innovation, & Centre for Heart Lung Innovation, University of British Columbia & St. Paul's Hospital, Canada (J.Z.S., G.S.G., J.L., S.K.S.).
Nicholas L CrudenCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.
Anna K BartonCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.ORCID 0000-0002-7953-3015
Neal G UrenCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.
Michelle C WilliamsCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.ORCID 0000-0003-3556-2428
Edwin J R van BeekEdinburgh Imaging, facility QMRI (E.J.R.v.B.), University of Edinburgh, UK.ORCID 0000-0002-2777-5071
Jonathon LeipsicDepartment of Radiology, Centre for Cardiovascular Innovation, & Centre for Heart Lung Innovation, University of British Columbia & St. Paul's Hospital, Canada (J.Z.S., G.S.G., J.L., S.K.S.).
Damini DeyDepartment of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (D.D., R.R.M., P.J.S., D.S.B.).ORCID 0000-0003-2236-6970
Raj R MakkarDepartment of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (D.D., R.R.M., P.J.S., D.S.B.).
Piotr J SlomkaDepartment of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (D.D., R.R.M., P.J.S., D.S.B.).ORCID 0000-0002-6110-938X
James H F RuddDivision of Cardiovascular Medicine, University of Cambridge, UK (J.M.T., J.H.F.R.).
David E NewbyCentre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.ORCID 0000-0001-7971-4628
Stephanie L Sellers *Department of Radiology, Centre for Cardiovascular Innovation, & Centre for Heart Lung Innovation, University of British Columbia & St. Paul's Hospital, Canada (J.Z.S., G.S.G., J.L., S.K.S.).
Daniel S Berman *Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (D.D., R.R.M., P.J.S., D.S.B.).
Marc R Dweck *Centre for Cardiovascular Science (E.T., T.R.G.C., A.F., M.K.D., R.B., N.L.C., A.K.B., N.G.U., M.C.W., E.J.R.v.B., D.E.N., M.R.D.), University of Edinburgh, UK.ORCID 0000-0001-9847-5917
MRC Centre for Reproductive Health · GBCedars-Sinai Medical Center · USSt. Paul's Hospital · CAInstitute of Cardiology · PLMACOM (United States) · USTwitter (United States) · USUnited States Nuclear Regulatory Commission · USUniversity of Cambridge · GBUniversity of Edinburgh · GB
Funding
Integrated analysis of coronary anatomy and biology with 18F-fluoride PET and CT angiographyR01HL135557 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SLOMKA, PIOTR J · 2017 to 2020
$3.0MBritish Heart Foundation CH/09/002British Heart Foundation CH/09/002/26360British Heart Foundation FS/13/77/30488British Heart Foundation FS/14/78/31020British Heart Foundation FS/17/79/33226British Heart Foundation FS/19/15/34155British Heart Foundation FS/CRTF/20/24086British Heart Foundation FS/ICRF/20/26002British Heart Foundation FS/TF/21/33008British Heart Foundation PG/19/40/34422British Heart Foundation RE/18/5/34216British Heart Foundation RG/16/10/32375British Heart Foundation SS/CH/09/002/26360Medical Research Council G0701127NHLBI NIH HHS R01 HL135557Wellcome TrustWellcome Trust 211100/Z/18/Z
Abstract
backgroundMajor uncertainties remain regarding disease activity within the retained native aortic valve, and regarding bioprosthetic valve durability, after transcatheter aortic valve implantation (TAVI). We aimed to assess native aortic valve disease activity and bioprosthetic valve durability in patients with TAVI in comparison with subjects with bioprosthetic surgical aortic valve replacement (SAVR).
methodsIn a multicenter cross-sectional observational cohort study, patients with TAVI or bioprosthetic SAVR underwent baseline echocardiography, computed tomography angiography, and
resultsIn patients with TAVI, native aortic valves demonstrated
conclusionsIn patients with TAVI, native aortic valves demonstrate evidence of ongoing active disease. Across imaging modalities, TAVI degeneration is of similar magnitude to bioprosthetic SAVR, suggesting comparable midterm durability. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02304276.
Indexed as
AgedAged, 80 and overAortic Valve DiseaseCohort StudiesCross-Sectional StudiesDisease ProgressionFemaleHeart Valve ProsthesisHumansMaleTranscatheter Aortic Valve Replacement18F-sodium fluorideaortic valvepositron emission tomography computed tomographytranscatheter aortic valve implantation
Identifiers
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Read underepoch 390
Registered trials
NCT02304276ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.