Evidence map›Paper›PMID 34455682›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2021

PNPLA3 and COVID-19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system.

Carlos J Pirola, Silvia Sookoian

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  2. Review
  3. Personalized medicine in nonalcoholic fatty liver disease.Clinical and molecular hepatology · 2022
    Article
  4. PNPLA3 and COVID-19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system.Liver international : official journal of the International Association for the Study of the Liver · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carlos J PirolaSchool of Medicine, Institute of Medical Research A Lanari, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0001-8234-4058
Silvia SookoianSchool of Medicine, Institute of Medical Research A Lanari, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0001-5929-5470
Consejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PUE 0055Fondo para la Investigación Científica y Tecnológica PICT 2016-0135Fondo para la Investigación Científica y Tecnológica PICT 2018-889
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Non-alcoholic Fatty Liver DiseaseBiologyGenetic Predisposition to DiseaseGenotypeHumansImmune SystemPolymorphism, Single NucleotideSARS-CoV-2

Identifiers

PMID34455682
PMCPMC8662082
OpenAlexW3196568901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.