Evidence map›Paper›PMID 34455521›Full record

ArticleClinical journal of gastroenterology2021

Immunoglobulin G4-related autoimmune hepatitis simultaneously concomitant with autoimmune pancreatitis: a case report.

Yoshihiro Yokoyama, Noriyuki Akutsu, Yasunao Numata, Keiko Okuda, Rena Morita, Yoshiharu Masaki, Hajime Sasaki, Ryo Suzuki, Takashi Yabana, Yoshiaki Arimura and 2 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. IgG4-Related Cholangitis.Seminars in liver disease · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yoshihiro YokoyamaDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan. yoko1215@sapmed.ac.jp.ORCID http://orcid.org/0000-0003-2434-1048
Noriyuki AkutsuDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Chuo-ku Sapporo, Sapporo, Hokkaido, S1W16060-8543, Japan.
Yasunao NumataDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Chuo-ku Sapporo, Sapporo, Hokkaido, S1W16060-8543, Japan.
Keiko OkudaDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan.
Rena MoritaDepartment of Clinical Pathology, Otaru City General Hospital, Otaru, Japan.
Yoshiharu MasakiDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Chuo-ku Sapporo, Sapporo, Hokkaido, S1W16060-8543, Japan.
Hajime SasakiDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan.
Ryo SuzukiDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan.
Takashi YabanaDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan.
Yoshiaki ArimuraDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan.
Yoshihiro KondoDepartment of Gastroenterology, Otaru City General Hospital, Otaru, Japan.
Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Chuo-ku Sapporo, Sapporo, Hokkaido, S1W16060-8543, Japan.
Otaru Municipal Hospital · JPSapporo Medical University · JP

Funding

the japanese society for the promotion of science (jsps) kakenhi JP20K16962
6 · The paper itself

Abstract

Thus far, there have been limited case reports on immunoglobulin G4-related autoimmune hepatitis (IgG4-AIH), and its clinical features have not been elucidated. We herein report a rare case of IgG4-AIH simultaneously concomitant with autoimmune pancreatitis (AIP). A 73-year-old female was admitted to our hospital for further investigation of elevated levels of liver transaminase and pancreatic enzymes. Her serological tests showed a high antinuclear antibody titer, and elevated IgG and IgG4 levels. Liver biopsy revealed interface hepatitis and bridging necrosis with IgG4-positive lymphoplasmacytic infiltration in the portal area. Moreover, contrast-enhanced computed tomography (CECT) showed pancreatic tail enlargement, and magnetic resonance cholangiopancreatography showed skipped narrowing of the main pancreatic duct in the pancreatic tail. Endoscopic ultrasonography-fine needle aspiration specimens showed no malignant cells. Based on these results, we diagnosed her with IgG4-AIH simultaneously concomitant with probable type 1 AIP. She was started on prednisolone (PSL) at 35 mg/d, and her symptoms and liver transaminase levels improved. One month after starting treatment, CECT showed improvement of pancreatic tail enlargement. She is maintained on 5 mg PSL/d and has been in remission for two years.

Indexed as

Autoimmune DiseasesAutoimmune PancreatitisHepatitis, AutoimmuneAgedBiopsy, Fine-NeedleCholangiopancreatography, Magnetic ResonanceFemaleHumansImmunoglobulin GImmunoglobulin GAutoimmune pancreatitisIgG4-related autoimmune hepatitisIgG4-related disease

Identifiers

PMID34455521
OpenAlexW3198095560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.