ArticleCerebral cortex (New York, N.Y. : 1991)2022
Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth.Frontiers in psychiatry · 2026Article
- Subcortical brain volume variations in autistic individuals across the lifespan.Molecular autism · 2025Article
- Subcortical shape alterations in children with Noonan syndrome spectrum: insights into genotype-phenotype associations.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years.Molecular autism · 2025Article
- PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.Nature neuroscience · 2025Article
- Alteration in Cortical Structure Mediating the Impact of Blood Oxygen-Carrying Capacity on Gross Motor Skills in Infants With Complex Congenital Heart Disease.Human brain mapping · 2025Article
- A review of applications of automated ventricular parcellation from magnetic resonance imaging of the brain.Frontiers in neurology · 2025Review
- Can optic nerve morphology in children with autism spectrum disorder be associated with atypical visual-sensory behaviors?Frontiers in psychiatry · 2025Article
- Autism-associated brain differences can be observed in utero using MRI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder.Human brain mapping · 2023Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents.Diagnostics (Basel, Switzerland) · 2023Article
- Striatal increase of dopamine receptor 2 density in idiopathic and syndromic mouse models of autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study.Frontiers in neuroscience · 2022Article
- Flattened Structural Network Changes and Association of Hyperconnectivity With Symptom Severity in 2-7-Year-Old Children With Autism.Frontiers in neuroscience · 2021Article
- Elucidation of Brain Morphogenesis Using Quantitative Brain Magnetic Resonance Imaging in Children.Pediatrics international : official journal of the Japan Pediatric SocietyReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Early interventions for autism spectrum disorder (ASD) are increasingly available, while only 42-50% of ASD children are diagnosed before 3 years old (YO). To identify neuroimaging biomarkers for early ASD diagnosis, we evaluated surface- and voxel-based brain morphometry in participants under 3YO who were later diagnosed with ASD. Magnetic resonance imaging data were retrospectively obtained from patients later diagnosed with ASD at Boston Children's Hospital. The ASD participants with comorbidities such as congenital disorder, epilepsy, and global developmental delay/intellectual disability were excluded from statistical analyses. Eighty-five structural brain magnetic resonance imaging images were collected from 81 participants under 3YO and compared with 45 images from 45 gender- and age-matched nonautistic controls (non-ASD). Using an Infant FreeSurfer pipeline, 236 regionally distributed measurements were extracted from each scan. By t-tests and linear mixed models, the smaller nucleus accumbens and larger bilateral lateral, third, and fourth ventricles were identified in the ASD group. Vertex-wise t-statistical maps showed decreased thickness in the caudal anterior cingulate cortex and increased thickness in the right medial orbitofrontal cortex in ASD. The smaller bilateral accumbens nuclei and larger cerebral ventricles were independent of age, gender, or gestational age at birth, suggesting that there are MRI-based biomarkers in prospective ASD patients before they receive the diagnosis and that the volume of the nucleus accumbens and cerebral ventricles can be key MRI-based early biomarkers to predict the emergence of ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.