Evidence map›Paper›PMID 34455430›Full record

ArticleEuropean heart journal2021

2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.

Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio, Israel Moshe Barbash, José A Barrabés, Giuseppe Boriani, Frieder Braunschweig, Michele Brignole and 15 more

Erratum issued 15 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 15 registered trials, which are not on this map. Cited by 733 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
733citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05327062 narecruitingnot on this mapstarted 2023, after this paper: background citation

CRT-DRIVE: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

TypeinterventionalSponsorXSpline S.p.A.Ran2023 to 2025Enrolled150ConditionsCardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch BlockArmsCRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
NCT05585411 narecruitingnot on this mapstarted 2022, after this paper: background citation

PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial

TypeinterventionalSponsorYonsei UniversityRan2022 to 2026Enrolled450ConditionsBradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area PacingArmsLeft bundle branch area pacing, Right ventricular pacing
NCT05721170 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Impact of Beta-blockers Among Patients Undergoing TAVI: a Randomized Multicenter Trial

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2024 to 2028Enrolled347ConditionsAortic Valve StenosisArmsBeta blocker
NCT05774262 narecruitingnot on this mapstarted 2023, after this paper: background citation

TELE-monitoring for Standard Pacemaker Implantation or Delayed Pacemaker Implantation After Autonomic/Electrophysiologic Evaluation and Cardioneuroablation for managEment of Functional atrioventriculaR Block - Randomized Controlled Study

TypeinterventionalSponsorAmerican Heart of PolandRan2023 to 2026Enrolled300ConditionsAtrioventricular BlockArmsPacemaker implantation, Cardioneuroablation (CNA)
NCT05776797 narecruitingnot on this mapstarted 2023, after this paper: background citation

AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation

TypeinterventionalSponsorUniversity Hospital OstravaRan2023 to 2029Enrolled480ConditionsRecurrent Atrial Fibrillation, Persistent Atrial FibrillationArmsAtrioventricular junction ablation in patients with cardiac resynchronization therapy (CRT), Optimal medication treatment in patients with cardiac resynchronization therapy (CRT)
NCT05889208 nanot yet recruitingnot on this mapstarted 2023, after this paper: background citation

Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation

TypeinterventionalSponsorAalborg University HospitalRan2023 to 2027Enrolled320ConditionsAortic Stenosis, Right Bundle-Branch BlockArmsProphylactic pacemaker implantation
NCT05896592 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Multicenter, Randomized, Double-blind, Research Study comparinG the Efficacy and Safety of cardioneuroablaTion vs Permanent Pacing in Patients With an implantabLE PACEmaker for Symptomatic Bradycardia.

TypeinterventionalSponsor4th Military Clinical Hospital with Polyclinic, PolandRan2024 to 2029Enrolled99ConditionsBradycardia, SyncopeArmsInvasive electrophysiological study, Extracardiac vagal stimulation, Cardioneuroablation, Redo cardioneuroablation, Implantation of the implantable loop recorder
NCT05966675 narecruitingnot on this mapstarted 2024, after this paper: background citation

Physiologic Cardiac Pacing to Prevent Left Ventricular Dysfunction Post Transcatheter Aortic Valve Implantation

TypeinterventionalSponsorMedical University of SilesiaRan2024 to 2028Enrolled500ConditionsAtrioventricular Block, Second and Third DegreeArmsconduction system pacing, right ventricular or biventricular pacing
NCT05993585 naunknown statusnot on this mapstarted 2024, after this paper: background citation

The Effects of Cardiac Resynchronisation Therapy on the Frank Starling Mechanism in Patients With Heart Failure

TypeinterventionalSponsorGuy's and St Thomas' NHS Foundation TrustRan2024 to 2025Enrolled40ConditionsPacemaker, HeartfailureArmsTest Of The Frank Starling Mechanism - Adjustment Of Av Delay And Measurement Of Pre-load -Control, Other: Test Of The Frank Starling Mechanism - Adjustment Of Av Delay And Measurement Of Pre-load -CRT
NCT06049992 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Stylet-driven vs. Lumenless Lead in Left-Bundle-Branch Pacing Randomized Trial

TypeinterventionalSponsorPuerta de Hierro University HospitalRan2023 to 2025Enrolled120ConditionsLeft Bundle-Branch PacingArmsPacemaker implantation with conduction system pacing using Lumenless leads, Pacemaker implantation with conduction system pacing using Stylet-driven leads
NCT06241651 narecruitingnot on this mapstarted 2024, after this paper: background citation

Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2024 to 2027Enrolled66ConditionsConduction System Pacing, Biventricular Pacing, Cardiac Resynchronization Therapy, Right Ventricular PacingArmsConduction system pacing, Biventricular pacing
NCT06262295 recruitingnot on this mapstarted 2024, after this paper: background citation

France LEADLESS, A Safety and Effectiveness Monitoring in France for AVEIR VR LP and AVEIR AR LP

Typeobservational_patient_registrySponsorFrench Cardiology SocietyRan2024 to 2029Enrolled1,000ConditionsPacemaker
NCT06311149 recruitingnot on this mapstarted 2023, after this paper: background citation

Multicenter Evaluation of Patients Using LATITUDE Monitoring System: Multitude Study

Typeobservational_patient_registrySponsorUniversity Hospital of FerraraRan2023 to 2043Enrolled20,000ConditionsCardiovascular Diseases, Arrhythmias, Cardiac, Heart Failure, Sudden Cardiac Death
NCT06602609 narecruitingnot on this mapstarted 2024, after this paper: background citation

Remote Acute Monitoring-based Same-day Discharge Strategy of Post Transcatheter Aortic Valve Implantation Patients Versus Standard Care at 30-Day Follow-up

TypeinterventionalSponsorImperial College LondonRan2024 to 2028Enrolled216ConditionsAortic Valve Stenosis, Cardiac Conduction Disturbance, Digital Health, Transcatheter Aortic Valve ImplantationArmsRemote Patient Monitoring Strategy, Standard Medical Therapy
NCT07664189 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Left Bundle Branch Pacing + Coronary Sinus Pacing Versus Left Bundle Branch Pacing Alone for Cardiac Resynchronization Therapy in Patients Eligible for CRT-P A Randomized Crossover Pilot Clinical Trial

TypeinterventionalSponsorClinica Cardio VIDRan2026 to 2027Enrolled10ConditionsHeart Failure Low OutputArmsLeft Bundle Branch Optimized CRT, Stimulation of the left bundle branch area (LBBAP)
3 · Its place in the literature

Who cites it

733 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Effectiveness of cardiac resynchronization therapy in cancer therapy-related cardiac dysfunction: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Pooled it
  3. Conduction system pacing for cardiac resynchronization therapy: a systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  4. Conduction System Pacing Versus Biventricular Cardiac Resynchronization in HFmrEF: A Systematic Review and Meta-Analysis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Redefining response to cardiac resynchronization therapy: a post hoc analysis of the MORE-CRT MPP trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Trial
  9. The Dutch Implantable Cardioverter-Defibrillator Decision Aid in Clinical Practice: A Stepped-Wedge Randomized Controlled Trial.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Trial
  10. Early Mobilization After Pacemaker Implantation.Pacing and clinical electrophysiology : PACE · 2026
    Trial
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673 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Michael Glikson
Jens Cosedis Nielsen
Mads Brix Kronborg
Yoav Michowitz
Angelo Auricchio
Israel Moshe Barbash
José A Barrabés
Giuseppe Boriani
Frieder Braunschweig
Michele Brignole
Haran Burri
Andrew J S Coats
Jean-Claude Deharo
Victoria Delgado
Gerhard-Paul Diller
Carsten W Israel
Andre Keren
Reinoud E Knops
Dipak Kotecha
Christophe Leclercq
Béla Merkely
Christoph Starck
Ingela Thylén
José Maria Tolosana
ESC Scientific Document Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiac Resynchronization TherapyHeart FailurePacemaker, ArtificialBradycardiaCardiac Pacing, ArtificialHumansalternate site pacingatrial fibrillationbradycardiacardiac pacingcardiac resynchronization therapycomplicationsconduction system pacingGuidelinesheart failurepacemakerpacing indicationspacing in TAVIsyncopetemporary pacing

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 9 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.