ArticleNeuroImage. Clinical2021
Aberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- Thalamic Microstructural Alterations as Revealed by the T1/T2 Ratio in Chronic Pain Patients.Journal of clinical medicine · 2025Article
- Lateral Ventricular Enlargement and Asymmetry and Myelin Content Imbalance in Individuals With Bipolar and Depressive Disorders: Clinical and Research Implications.Bipolar disorders · 2025Article
- Depression-associated reductions in putaminal volume are accompanied by a shift from matrix-like to striosome-like structural connectivity.Frontiers in psychiatry · 2025Article
- The Relationship Between Reduced Hand Dexterity and Brain Structure Abnormality in Older Adults.Geriatrics (Basel, Switzerland) · 2024Article
- Sex Differences in Depression: Insights from Multimodal Gray Matter Morphology and Peripheral Inflammatory Factors.International journal of molecular sciences · 2024Article
- Microstructural asymmetry in the human cortex.Nature communications · 2024Article
- Demyelination in Patients with POST-COVID Depression.Journal of clinical medicine · 2024Article
- Intracortical myelin across laminae in adult individuals with 47,XXX: a 7 Tesla MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder.Translational psychiatry · 2024Article
- FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury.Military Medical Research · 2024Article
- Anonymization and validation of three-dimensional volumetric renderings of computed tomography data using commercially available T1-weighted magnetic resonance imaging-based algorithms.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity.Theranostics · 2023Article
- Behavioral and neuroimaging evidence prodromal to major depressive disorder onset in a young adult without personal or family history of psychiatric disorder: Case report.Psychiatry research case reports · 2022Article
- Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders.Frontiers in neuroscience · 2022Article
- Protocol for a machine learning algorithm predicting depressive disorders using the T1w/T2w ratio.MethodsX · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The association between depressive disorders and measures reflecting myelin content is underexplored, despite growing evidence of associations with white matter tract integrity. We characterized the T1w/T2w ratio using the Glasser atlas in 39 UD and 47 HC participants (ages = 19-44, 75% female). A logistic elastic net regularized regression with nested cross-validation and a subsequent linear discriminant analysis conducted on held-out samples were used to select brain regions and classify patients vs. healthy controls (HC). True-label model performance was compared against permuted-label model performance. The T1w/T2w ratio distinguished patients from HC with 68% accuracy (p < 0.001; sensitivity = 63.8%, specificity = 71.5%). Brain regions contributing to this classification performance were located in the orbitofrontal cortex, anterior cingulate, extended visual, and auditory cortices, and showed statistically significant differences in the T1w/T2w ratio for patients vs. HC. As the T1w/T2w ratio is thought to characterize cortical myelin, patterns of cortical myelin in these regions may be a biomarker distinguishing individuals with depressive disorders from HC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.