Evidence map›Paper›PMID 34455147›Full record

ArticleRedox biology2021

Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides.

Christiane Ott, Florencia Tomasina, Nicolás Campolo, Silvina Bartesaghi, Mauricio Mastrogiovanni, Alejandro Leyva, Carlos Batthyány, Walter Meinl, Tilman Grune, Rafael Radi

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion inbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Christiane OttDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany.
Florencia TomasinaDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay.
Nicolás CampoloDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay.
Silvina BartesaghiDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay.
Mauricio MastrogiovanniDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay.
Alejandro LeyvaAnalytical Biochemistry and Proteomics Unit, Instituto de Investigaciones Biológicas Clemente Estable & Institut Pasteur de Montevideo, Montevideo, Uruguay.
Carlos BatthyányCentro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay; Analytical Biochemistry and Proteomics Unit, Instituto de Investigaciones Biológicas Clemente Estable & Institut Pasteur de Montevideo, Montevideo, Uruguay.
Walter MeinlDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Tilman GruneDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria. Electronic address: Tilman.Grune@dife.de.
Rafael RadiDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay. Electronic address: rradi@fmed.edu.uy.
Universidad de la República de Uruguay · UYGerman Centre for Cardiovascular Research · DEGerman Institute of Human Nutrition · DEInstitut Pasteur de Montevideo · UYUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Removal of moderately oxidized proteins is mainly carried out by the proteasome, while highly modified proteins are no longer degradable. However, in the case of proteins modified by nitration of tyrosine residues to 3-nitrotyrosine (NO

Indexed as

Proteasome Endopeptidase ComplexTyrosinePeptidesProteins3-nitrotyrosinePeptidesProteasome Endopeptidase ComplexProteinsTyrosineCytochrome cNitrotyrosinePeroxynitriteProteasome activityProtein oxidation

Identifiers

PMID34455147
PMCPMC8403764
OpenAlexW2899107360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.