Evidence map›Paper›PMID 34455081›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

The drop in reported invasive pneumococcal disease among adults during the first COVID-19 wave in the Netherlands explained.

Kirsten K T Dirkx, Bert Mulder, Annelies S Post, Martijn H Rutten, Caroline M A Swanink, Heiman F L Wertheim, Amelieke J H Cremers

Open access · goldAbstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. SARS-CoV-2 andFrontiers in cellular and infection microbiology · 2025
    Observational
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. A Pandemic Lesson for Global Lung Diseases: Exacerbations Are Preventable.American journal of respiratory and critical care medicine · 2022
    Review
  9. Article
  10. Article
  11. Increase in invasive disease caused byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kirsten K T DirkxDepartment of Clinical Microbiology and Infectious Diseases, Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands; Department of Clinical Microbiology, Radboud Centre for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands.
Bert MulderDepartment of Clinical Microbiology and Infectious Diseases, Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands.
Annelies S PostDepartment of Clinical Microbiology and Infectious Diseases, Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands.
Martijn H RuttenDepartment of Primary and Community Care, Radboud University Medical Centre, Nijmegen, The Netherlands.
Caroline M A SwaninkDepartment of Clinical Microbiology and Immunology, Rijnstate, Arnhem, the Netherlands.
Heiman F L WertheimDepartment of Clinical Microbiology, Radboud Centre for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands.
Amelieke J H CremersDepartment of Clinical Microbiology, Radboud Centre for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands.
Radboud University Nijmegen · NLCanisius-Wilhelmina Ziekenhuis · NLRijnstate Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesStreptococcus pneumoniae is the leading bacterial pathogen causing respiratory infections. Since the COVID-19 pandemic emerged, less invasive pneumococcal disease (IPD) was identified by surveillance systems worldwide. Measures to prevent transmission of SARS-CoV-2 also reduce transmission of pneumococci, but this would gradually lead to lower disease rates.

designHere, we explore additional factors contributing to the instant drop in pneumococcal disease cases captured in surveillance.

resultsOur observations on referral practices and other impediments to diagnostic testing indicate that residual IPD has likely occurred but remained undetected by conventional hospital-based surveillance.

conclusionsDepending on the setting, we discuss alternative monitoring strategies that could improve understanding of pneumococcal disease dynamics.

Indexed as

COVID-19Pneumococcal InfectionsAdultHumansIncidenceInfantNetherlandsPandemicsPneumococcal VaccinesSARS-CoV-2Pneumococcal VaccinesCOVID-19IPDPandemicS. pneumoniaeSurveillance

Identifiers

PMID34455081
PMCPMC8444629
OpenAlexW3196342145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.