Evidence map›Paper›PMID 34454926›Full record

ArticleEuropean journal of pharmacology2021

Na

Hirotake Ishida, Momoka Yamaguchi, Shin-Ya Saito, Takuma Furukawa, John L Shannonhouse, Yu Shin Kim, Tomohisa Ishikawa

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hirotake IshidaDepartment of Pharmacology, School of Pharmaceutical Sciences, University of Shizuka, 52-1 Yada, Suruga Ward, Shizuoka City,Shizuoka, 422-8526, Japan; Department of Oral & Maxillofacial Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.
Momoka YamaguchiDepartment of Pharmacology, School of Pharmaceutical Sciences, University of Shizuka, 52-1 Yada, Suruga Ward, Shizuoka City,Shizuoka, 422-8526, Japan.
Shin-Ya SaitoDepartment of Pharmacology, School of Pharmaceutical Sciences, University of Shizuka, 52-1 Yada, Suruga Ward, Shizuoka City,Shizuoka, 422-8526, Japan; Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari City, Ehime, 794-8555, Japan.
Takuma FurukawaDepartment of Pharmacology, School of Pharmaceutical Sciences, University of Shizuka, 52-1 Yada, Suruga Ward, Shizuoka City,Shizuoka, 422-8526, Japan.
John L ShannonhouseDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.
Yu Shin KimDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA; Programs in Integrated Biomedical Sciences & Translational Sciences, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.
Tomohisa IshikawaDepartment of Pharmacology, School of Pharmaceutical Sciences, University of Shizuka, 52-1 Yada, Suruga Ward, Shizuoka City,Shizuoka, 422-8526, Japan. Electronic address: ishikat@u-shizuoka-ken.ac.jp.
University of Shizuoka · JPThe University of Texas Health Science Center at San Antonio · USOkayama University of Science · JP

Funding

Coupling activation of primary sensory neurons as a novel plasticity mechanism for chronic painR01DE026677 · NIDCR · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KIM, YU SHIN · 2017 to 2021
$1.8M
NIDCR NIH HHS R01 DE026677
6 · The paper itself

Abstract

Reduced skin blood flow has been reported in neuropathic pain patients as well as various peripheral neuropathic pain model animals. We have previously shown that vasodilators, which improves reduced skin blood flow, correlatively alleviate neuropathic pain in chronic constriction injury (CCI) mice, a model of neuropathic pain from peripheral nerve injury. Here, we sought to elucidate the mechanism underlying the reduced skin blood flow in CCI rats. The skin blood flow of the ipsilateral plantar arteries was significantly reduced compared to that of the contralateral ones 4 weeks after loose ligation of the sciatic nerve. The contraction induced by noradrenaline, serotonin, and U46619, a thromboxane receptor agonist, in the isolated ipsilateral plantar arteries was significantly enhanced compared to that in the contralateral ones. KB-R7943, a Na

Indexed as

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAmilorideAnimalsArteriesBlood CirculationBoron CompoundsCalcimycinCalciumCalcium IonophoresDisease Models, AnimalDose-Response Relationship, DrugMaleMuscle ContractionNeuralgiaNifedipineNorepinephrine15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-aminoethoxydiphenyl borateAmilorideBoron CompoundsCalcimycinCalciumCalcium IonophoresNifedipineNorepinephrineOuabainSerotoninSodiumSodium-Calcium ExchangerThioureaVasoconstrictor AgentsVasodilator AgentsArteriesChronic constriction injuryNeuropathic painSodium-calcium exchangerVasoconstriction

Identifiers

PMID34454926
PMCPMC8518190
OpenAlexW3193754739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.