ReviewNeuropharmacology2021
Covid-19 interface with drug misuse and substance use disorders.
Review in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Comparison of Mental Illness Comorbidity Pre-Pandemic vs. Pandemic-Era and Associations with Clinical and Demographic Characteristics for Virginia Public Hospital Inpatient Discharges with a Substance Use Disorder.International journal of environmental research and public health · 2026Article
- Trends of incident stimulant use disorder diagnoses before and after the COVID-19 pandemic in British Columbia (2013-2024): a population-based study.Frontiers in psychiatry · 2026Article
- A pain from the nose to the head: neurological commitment during long COVID.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- COVID-19 and the Syndemic of Intimate Partner Violence, Mental Health, Substance Use, and HIV Care Engagement Among Black Sexual Minority Men Living with HIV in the US South.International journal of environmental research and public health · 2025Article
- Large-Scale Deep Learning-Enabled Infodemiological Analysis of Substance Use Patterns on Social Media: Insights From the COVID-19 Pandemic.JMIR infodemiology · 2025Article
- Transcriptomic Profile of the Male Rat Hypothalamus and Nucleus Accumbens After Paroxetine Treatment and Withdrawal: Possible Causes of Sexual Dysfunction.Molecular neurobiology · 2025Article
- Global, regional and national burden of drug use disorders, 1990-2021: decomposition analysis, health inequality analysis and predictions to 2035.Frontiers in public health · 2025Article
- Differences in the Rates of Diagnoses of Mental and Behavioral Disorders Due to Psychoactive Substance Use by Sex and Age during Pre-Pandemic and COVID-19 Pandemic Periods in Kazakhstan.Healthcare (Basel, Switzerland) · 2024Article
- Walk-in mental health: Bridging barriers in a pandemic.PloS one · 2024Article
- Article
- Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine.Molecular and cellular neurosciences · 2023Article
- Meaning in challenging times: Sense of meaning supports wellbeing despite pandemic stresses.SSM. Mental health · 2023Article
- TLR3 activation with poly I:C exacerbates escalated alcohol consumption in dependent male C57BL/6J mice.The American journal of drug and alcohol abuse · 2023Article
- Drug consumption in German cities and municipalities during the COVID-19 lockdown: a wastewater analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- The development and validation of the pandemic medication-assisted treatment questionnaire for the assessment of pandemic crises impact on medication management and administration for patients with opioid use disorders.Nordisk alkohol- & narkotikatidskrift : NAT · 2023Article
- Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine.bioRxiv : the preprint server for biology · 2023Article
- Impact of COVID-19 on the characteristics of opioid overdose deaths in Arkansas.The International journal on drug policy · 2022Article
- Self-perceived substance and behavioral addictions among Jewish Israeli adolescents during the COVID-19 pandemic.Addictive behaviors reports · 2022Article
- Potential roles of the gut microbiota in the manifestations of drug use disorders.Frontiers in psychiatry · 2022Review
- Conceptualizing COVID-19 syndemics: A scoping review.Journal of multimorbidity and comorbidityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The coronavirus disease 2019 (Covid-19) pandemic intensified the already catastrophic drug overdose and substance use disorder (SUD) epidemic, signaling a syndemic as social isolation, economic and mental health distress, and disrupted treatment services disproportionally impacted this vulnerable population. Along with these social and societal factors, biological factors triggered by intense stress intertwined with incumbent overactivity of the immune system and the resulting inflammatory outcomes may impact the functional status of the central nervous system (CNS). We review the literature concerning SARS-CoV2 infiltration and infection in the CNS and the prospects of synergy between stress, inflammation, and kynurenine pathway function during illness and recovery from Covid-19. Taken together, inflammation and neuroimmune signaling, a consequence of Covid-19 infection, may dysregulate critical pathways and underlie maladaptive changes in the CNS, to exacerbate the development of neuropsychiatric symptoms and in the vulnerability to develop SUD. This article is part of the special Issue on 'Vulnerabilities to Substance Abuse'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.