Evidence map›Paper›PMID 34454876›Full record

ReviewJACC. Clinical electrophysiology2021

Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk.

Ning Jiang, Anyu Zhou, Hafiz Imran, Guangbin Shi, Bahaa Kaseer, Vincent Siu, Antony F Chu, David M Donaldson, Malcolm M Kirk, Binu B Philips and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Clinical electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ning JiangLifespan Cardiovascular Institute, Brown University, Providence, Rhode Island, USA.
Anyu ZhouDepartment of Medicine, Brown University, Providence, Rhode Island, USA.
Hafiz ImranDepartment of Medicine, Brown University, Providence, Rhode Island, USA.
Guangbin ShiDepartment of Medicine, Brown University, Providence, Rhode Island, USA.
Bahaa KaseerDepartment of Medicine, Brown University, Providence, Rhode Island, USA.
Vincent SiuCardiology Division, University of Toronto, Toronto, Ontario, Canada.
Antony F ChuDepartment of Medicine, Brown University, Providence, Rhode Island, USA.
David M DonaldsonDepartment of Medicine, University of California at Irvine, Irvine, California, USA.
Malcolm M KirkDepartment of Medicine, Brown University, Providence, Rhode Island, USA.
Binu B PhilipsDepartment of Medicine, Mount Auburn Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Samuel C DudleyDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: sdudley@umn.edu.
Brown University · USMount Auburn Hospital · USUniversity of California, Irvine · USUniversity of Minnesota · USUniversity of Toronto · CA

Funding

Na+ channel mRNA splicing in heart failureR01HL104025 · NHLBI · UNIVERSITY OF MINNESOTA · PI DUDLEY, SAMUEL C · 2011 to 2019
$3.3M
Metabolic Regulation of Sodium ChannelsR01HL106592 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDLEY, SAMUEL C · 2011 to 2014
$1.6M
NHLBI NIH HHS R01 HL104025NHLBI NIH HHS R01 HL106592
6 · The paper itself

Abstract

Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure. CRT was associated with a decreased proportion of circulating, nonfunctional sodium channels and improved SERCA2a mRNA expression. Patients without CRT did not have improvement in the biomarkers. These changes might explain the lower arrhythmic risk and improved contractility associated with CRT.

Indexed as

Cardiac Resynchronization TherapyBiomarkersCalciumDeath, SuddenHumansSarcoplasmic ReticulumBiomarkersCalciumbiomarkercalciumimplantable cardioverter-defibrillatorion channelssodium channel

Identifiers

PMID34454876
PMCPMC8463435
OpenAlexW3193793188

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.