Evidence map›Paper›PMID 34454875›Full record

ArticleJACC. Clinical electrophysiology2022

Arrhythmic and Mortality Outcomes Among Ischemic Versus Nonischemic Cardiomyopathy Patients Receiving Primary ICD Therapy.

Craig R Narins, Mehmet K Aktas, Anita Y Chen, Scott McNitt, Fred S Ling, Arwa Younis, Wojciech Zareba, James P Daubert, David T Huang, Spencer Rosero and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Predictors of echocardiographic response in the Budapest-CRT upgrade trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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  6. CHAFrontiers in cardiovascular medicine · 2026
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  12. Prognostic value of late gadolinium enhancement cardiac MRI for ICD therapy in non-ischaemic cardiomyopathy : A 5-year cohort study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Craig R NarinsDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA. Electronic address: craig_narins@urmc.rochester.edu.
Mehmet K AktasDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA.
Anita Y ChenClinical Cardiovascular Research Center, University of Rochester, Rochester, New York, USA; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Scott McNittClinical Cardiovascular Research Center, University of Rochester, Rochester, New York, USA.
Fred S LingDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA.
Arwa YounisClinical Cardiovascular Research Center, University of Rochester, Rochester, New York, USA.
Wojciech ZarebaDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA; Clinical Cardiovascular Research Center, University of Rochester, Rochester, New York, USA.
James P DaubertDivision of Cardiology, Duke University, Durham, North Carolina, USA.
David T HuangDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA.
Spencer RoseroDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA.
Valentina KutyifaDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA; Clinical Cardiovascular Research Center, University of Rochester, Rochester, New York, USA.
Ilan GoldenbergDivision of Cardiology, University of Rochester Medical Center, Rochester, New York, USA; Clinical Cardiovascular Research Center, University of Rochester, Rochester, New York, USA.
University of Rochester Medical Center · USUniversity of Rochester · USDuke University · US

Funding

Late Sodium Current Blockade in High-Risk ICD Patients - CCC - Lead ApplicationU01HL096607 · NHLBI · UNIVERSITY OF ROCHESTER · PI ZAREBA, WOJCIECH · 2010 to 2015
$5.9M
NHLBI NIH HHS U01 HL096607
6 · The paper itself

Abstract

objectivesThis study sought to determine the association of cardiomyopathy etiology with the likelihood of ventricular arrhythmias, appropriate implantable cardioverter-defibrillator (ICD) therapy, and mortality.

backgroundThere are conflicting data on the benefit of primary prevention ICD therapy in patients with ischemic versus nonischemic cardiomyopathy (ICM/NICM).

methodsThe study population comprised 4803 patients with ICM (n = 3,106) or NICM (n = 1,697) with a primary prevention ICD enrolled in 5 randomized trials conducted between 1997 and 2017. The primary end point was sustained ventricular tachycardia (VT) ≥200 beats/min or ventricular fibrillation (VF). Secondary end points included appropriate ICD therapy and all-cause mortality. Differences in cause-specific mortality, including noncardiac, sudden cardiac, and non-sudden cardiac death, were also examined.

resultsPatients with ICM were significantly older and had more comorbid conditions, whereas those with NICM had a more advanced heart failure class at enrollment and were more often prescribed medical or cardiac resynchronization therapy for heart failure. Multivariate analysis showed that ICM versus NICM had a similar risk of VT/VF events (HR: 0.98 [95% CI: 0.79-1.20]) and appropriate ICD therapy (HR: 1.03 [95% CI: 0.87-1.22]), whereas the risk of all-cause mortality was 1.8-fold higher among ICM versus NICM patients (HR: 1.84 [95% CI: 1.42-2.38]), dominated by non-sudden cardiac mortality.

conclusionsCombined data from 5 landmark ICD clinical trials show that ICM patients experience a similar risk of life-threatening ventricular arrhythmic events but have an increased risk of all-cause mortality, dominated by non-sudden cardiac death, compared with NICM patients.

Indexed as

Cardiac Resynchronization TherapyCardiomyopathiesDefibrillators, ImplantableTachycardia, VentricularArrhythmias, CardiacHumanscardiomyopathiesimplantable defibrillatorssudden deathventricular arrhythmias

Identifiers

PMID34454875
PMCPMC8792162
OpenAlexW3195237678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.