Evidence map›Paper›PMID 34454619›Full record

ArticleJournal of physiological anthropology2021

Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico.

Pilar E Núñez Ortega, María E Meneses, Iván Delgado-Enciso, César Antonio Irecta-Nájera, Itandehui Castro-Quezada, Roberto Solís-Hernández, Elena Flores-Guillén, Rosario García-Miranda, Adán Valladares-Salgado, Daniel Locia-Morales and 1 more

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Article in Journal of physiological anthropology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Exploring the Association ofBiomolecules · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pilar E Núñez OrtegaHealth Department, El Colegio de La Frontera Sur, San Cristóbal de Las Casas, Chiapas, Mexico.
María E MenesesNational Council for Science and Technology, Postgraduate College Campus Puebla, Puebla, Mexico.
Iván Delgado-EncisoFacultad de Medicina, Universidad de Colima, Colima, Mexico.
César Antonio Irecta-NájeraHealth Department, El Colegio de La Frontera Sur, Villahermosa, Tabasco, Mexico.
Itandehui Castro-QuezadaHealth Department, El Colegio de La Frontera Sur, San Cristóbal de Las Casas, Chiapas, Mexico.
Roberto Solís-HernándezHealth Department, El Colegio de La Frontera Sur, San Cristóbal de Las Casas, Chiapas, Mexico.
Elena Flores-GuillénFaculty of Nutrition and Food Science, University of Science and Arts of Chiapas, Tuxtla Gutiérrez, Chiapas, Mexico.
Rosario García-MirandaHealth Department, El Colegio de La Frontera Sur, San Cristóbal de Las Casas, Chiapas, Mexico.
Adán Valladares-SalgadoUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Daniel Locia-MoralesUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Héctor Ochoa-Díaz-LópezHealth Department, El Colegio de La Frontera Sur, San Cristóbal de Las Casas, Chiapas, Mexico. hochoa@ecosur.mx.

Funding

Consejo Nacional de Ciencia y Tecnología 1676
6 · The paper itself

Abstract

backgroundMetabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.

methodsIn a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.

resultsThe MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007).

conclusionsWomen from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.

Indexed as

Indians, North AmericanMetabolic SyndromeAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOCross-Sectional StudiesFemaleHumansMexicoMiddle AgedPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanChiapasFTOMayan indigenous womenMetabolic syndromeMexicoSingle nucleotide polymorphisms

Identifiers

PMID34454619
PMCPMC8403373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.