Evidence map›Paper›PMID 34454573›Full record

ArticleTrials2021

"More air-better performance-faster recovery": study protocol for randomised controlled trial of the effect of post-stroke inspiratory muscle training for adults.

Susanne Lillelund Sørensen, Simon Svanborg Kjeldsen, Sine Secher Mortensen, Ulla Torp Hansen, Dorthe Hansen, Asger Roger Pedersen, Hanne Pallesen

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04686019 ("More Air - Better Performance - Faster Recovery"), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04686019 naunknown statusnot on this map

"More Air - Better Performance - Faster Recovery": Study Protocol for a Randomised Controlled Trial of the Effect of Inspiratory Muscle Training for Adults Post-stroke

TypeinterventionalSponsorCentral Jutland Regional HospitalRan2021 to 2023Enrolled80ConditionsFunctional Independence, Respiratory InsufficiencyArmsInspiratory muscle training (IMT)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. The effect of breathing training on swallowing function in patients with neurogenic dysphagia: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Susanne Lillelund SørensenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark.ORCID http://orcid.org/0000-0002-1315-3546
Simon Svanborg KjeldsenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark. simokjel@rm.dk.
Sine Secher MortensenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark.
Ulla Torp HansenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark.
Dorthe HansenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark.
Asger Roger PedersenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark.
Hanne PallesenHammel Neurorehabilitation Centre and University Research Clinic, RM, University of Aarhus, Voldbyvej 15, 8450, Hammel, Denmark.
Aarhus University · DK

Funding

Helsefonden 20-A-0064
6 · The paper itself

Abstract

backgroundStroke results in varying physical, cognitive, emotional and/or social disabilities in the short and long term alike. Motor impairments are important, persistent consequences of stroke and include, among others, decreased respiratory muscle function, decreased ability to expand the thorax and postural dysfunction. These deficits affect the patient's ability to perform daily activities, produce fatigue and reduce endurance and quality of life. Inspiratory muscle training (IMT) aims to improve the strength and endurance of the diaphragm and the external intercostal muscles. The objectives of this study are to investigate the effect of 3 weeks of IMT on (i) maximal inspiratory pressure (MIP) in adults having suffered a stroke, as well as (ii) functional activities and expiratory measurements. METHODS/

designThis is a randomised controlled trial (RCT) comparing IMT with conventional neurorehabilitation (usual practice). The trial will include 80 patients with reduced MIP hospitalised at a specialised neurorehabilitation hospital in Denmark. The intervention group will receive IMT sessions, exercising at 30% of MIP. Patients in the intervention group will perform two daily sessions (one session of IMT with Threshold IMT consisting of two times 15 inspirations at normal breathing rhythm (5-10 min)), 7 days a week for 3 weeks. Training can be with or without physiotherapist supervision. STUDY OUTCOMES: MIP assessed by the Power Breath, Functional Independence Measurement, The 6-min walk test, the Fatigue Severity Scale and average voice volume. Expiratory function will be assessed using spirometry. All assessments will be conducted at baseline and 3 weeks (at termination of the intervention) and 3 months after the intervention has concluded. DISCUSSION: IMT is a promising and partly self-managed tool for rehabilitation to improve respiratory function. The introduction of IMT in combination with traditional physical therapy may enhance faster recovery after stroke and may at the same time demand little personnel resources to increase training intensity. This trial will provide further evidence of IMT to clinicians, patients and health managers. Hereby, this study accepts the call for further research.

trial registrationClinicalTrials.gov NCT04686019 . Registered on 28 December 2020.

Indexed as

Physical TherapistsStrokeAdultExerciseHumansPhysical Therapy ModalitiesRandomized Controlled Trials as TopicRespiratory MusclesActivity of daily livingEndurance in gaitFatigueInspiratory muscle trainingPeak expiratory flowSpirometryStrokeVoice volume and phonation

Identifiers

PMID34454573
PMCPMC8401331
OpenAlexW3166566148

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.