Evidence map›Paper›PMID 34454271›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021

Quantitative EEG improves prediction of Sturge-Weber syndrome in infants with port-wine birthmark.

Ryan E Gill, Bohao Tang, Lindsay Smegal, Jack H Adamek, Danielle McAuliffe, Balaji M Lakshmanan, Siddharth Srivastava, Angela M Quain, Alison J Sebold, Doris D M Lin and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Biomarker development in Sturge-Weber syndrome.Journal of neurodevelopmental disorders · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Current concepts of vascular anomalies.Archives of craniofacial surgery · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ryan E GillKennedy Krieger Institute, Baltimore, MD, USA; Johns Hopkins University, Baltimore, MD, USA.
Bohao TangJohns Hopkins University, Baltimore, MD, USA.
Lindsay SmegalKennedy Krieger Institute, Baltimore, MD, USA.
Jack H AdamekKennedy Krieger Institute, Baltimore, MD, USA.
Danielle McAuliffeKennedy Krieger Institute, Baltimore, MD, USA.
Balaji M LakshmananKennedy Krieger Institute, Baltimore, MD, USA.
Siddharth SrivastavaKennedy Krieger Institute, Baltimore, MD, USA; Johns Hopkins University, Baltimore, MD, USA.
Angela M QuainKennedy Krieger Institute, Baltimore, MD, USA.
Alison J SeboldKennedy Krieger Institute, Baltimore, MD, USA.
Doris D M LinJohns Hopkins University, Baltimore, MD, USA.
Eric H KossoffJohns Hopkins University, Baltimore, MD, USA.
Brian CaffoJohns Hopkins University, Baltimore, MD, USA.
Anne M ComiKennedy Krieger Institute, Baltimore, MD, USA; Johns Hopkins University, Baltimore, MD, USA.
Joshua B EwenKennedy Krieger Institute, Baltimore, MD, USA; Johns Hopkins University, Baltimore, MD, USA. Electronic address: ewen@kennedykrieger.org.
Kennedy Krieger Institute · USJohns Hopkins University · US

Funding

VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAUGHNAN, MARIE E · 2009 to 2023
$20.8M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
NEUROLOGY SCIENCES ACADEMIC DEVELOPMENT AWARD (NSADA)K12NS001696 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JOHNSTON, MICHAEL VAN DOREN · 1993 to 2016
$3.8M
EEG-Based Assessment of Functional Connectivity in AutismK23NS073626 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI EWEN, JOSHUA B · 2011 to 2015
$876k
NICHD NIH HHS P50 HD103538NINDS NIH HHS K12 NS001696NINDS NIH HHS K23 NS073626NINDS NIH HHS U54 NS065705
6 · The paper itself

Abstract

objectivePort-wine birthmark (PWB) is a common occurrence in the newborn, and general pediatricians, dermatologists, and ophthalmologists are often called on to make an assessment of risk for Sturge-Weber syndrome (SWS) due to workforce shortages in pediatric neurologists and MRI's low sensitivity for SWS brain involvement in infants. We therefore aimed to develop a quantitative EEG (qEEG) approach to safely screen young infants with PWB for SWS risk and optimal timing of diagnostic MRI.

methodsForty-eight infants (prior to first birthday) underwent EEG recording. Signal processing methods compared voltage between left and right sides using a previously defined pipeline and diagnostic threshold. In this test sample, we compared sensitivity/specificity of the qEEG metric against MRI performed after the first birthday. We also used likelihood ratio testing to determine whether qEEG adds incremental information beyond topographical extent of PWB, another risk marker of brain involvement.

resultsqEEG helped predict SWS risk in the first year of life (p = 0.031), with a sensitivity of 50% and a specificity of 81%. It added about 40% incremental information beyond PWB extent alone (p = 0.042).

conclusionqEEG adds information to risk prediction in infants with facial PWB. SIGNIFICANCE: qEEG can be used to help determine whether to obtain an MRI in the first year of life. The data collected can assist in developing a predictive model risk calculator that incorporates both PWB extent and qEEG results, which can be validated and then employed in the community.

Indexed as

Cohort StudiesElectroencephalographyFemaleHumansInfantInfant, NewbornMalePort-Wine StainPredictive Value of TestsProspective StudiesSturge-Weber SyndromeDiagnostic biomarkerIschemiaPort-wine birthmarkPredictive modelPrognostic biomarkerQuantitative EEGSturge-Weber syndrome

Identifiers

PMID34454271
PMCPMC8478826
OpenAlexW3189657455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.