Evidence map›Paper›PMID 34454266›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021

Spontaneous modulations of high-frequency cortical activity.

Hiroya Ono, Masaki Sonoda, Brian H Silverstein, Kaori Sonoda, Takafumi Kubota, Aimee F Luat, Robert Rothermel, Sandeep Sood, Eishi Asano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hiroya OnoDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Pediatric Neurology, National Center of Neurology and Psychiatry, Joint Graduate School of Tohoku University, Tokyo 1878551, Japan.
Masaki SonodaDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama 2360004, Japan.
Brian H SilversteinTranslational Neuroscience Program, Wayne State University, Detroit, MI 48201, USA.
Kaori SonodaDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama 2360004, Japan.
Takafumi KubotaDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Neurology, University Hospitals of Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Aimee F LuatDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Neurology, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Pediatrics, Central Michigan University, Mt. Pleasant, MI 48858, USA.
Robert RothermelDepartment of Psychiatry, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA.
Sandeep SoodDepartment of Neurosurgery, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA.
Eishi AsanoDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Department of Neurology, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA; Translational Neuroscience Program, Wayne State University, Detroit, MI 48201, USA. Electronic address: easano@med.wayne.edu.
Wayne State University · USCentral Michigan University · US

Funding

Functional brain mapping in pediatric neurosurgeryR01NS064033 · NINDS · WAYNE STATE UNIVERSITY · PI EISHI ASANO · 2009 to 2026
$5.7M
NINDS NIH HHS R01 NS064033
6 · The paper itself

Abstract

objectiveWe clarified the clinical and mechanistic significance of physiological modulations of high-frequency broadband cortical activity associated with spontaneous saccadic eye movements during a resting state.

methodsWe studied 30 patients who underwent epilepsy surgery following extraoperative electrocorticography and electrooculography recordings. We determined whether high-gamma activity at 70-110 Hz preceding saccade onset would predict upcoming ocular behaviors. We assessed how accurately the model incorporating saccade-related high-gamma modulations would localize the primary visual cortex defined by electrical stimulation.

resultsThe dynamic atlas demonstrated transient high-gamma suppression in the striatal cortex before saccade onset and high-gamma augmentation subsequently involving the widespread posterior brain regions. More intense striatal high-gamma suppression predicted the upcoming saccade directed to the ipsilateral side and lasting longer in duration. The bagged-tree-ensemble model demonstrated that intense saccade-related high-gamma modulations localized the visual cortex with an accuracy of 95%.

conclusionsWe successfully animated the neural dynamics supporting saccadic suppression, a principal mechanism minimizing the perception of blurred vision during rapid eye movements. The primary visual cortex per se may prepare actively in advance for massive image motion expected during upcoming prolonged saccades. SIGNIFICANCE: Measuring saccade-related electrocorticographic signals may help localize the visual cortex and avoid misperceiving physiological high-frequency activity as epileptogenic.

Indexed as

AdolescentChildChild, PreschoolDrug Resistant EpilepsyElectrocorticographyFemaleGamma RhythmHumansMaleSaccadesVisual CortexYoung Adult4D brain mappingAnimationArtificial intelligenceEloquent areaHigh-frequency oscillation (HFO)Intracranial recordingMachine learningPediatric epilepsy surgeryPerceptionPhosphineRipplesSaccadic eye movementsVideo EEG monitoring

Identifiers

PMID34454266
PMCPMC8478828
OpenAlexW3153477467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.