ArticleCurrent biology : CB2021
Energy compensation and adiposity in humans.
Registry-linked trialAbstract read
In one paragraph
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06923163 (Metabolic Response of Sedentary Participants to a Long-term Exercise Intervention), which is not on this map. Cited by 69 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Response of Sedentary Participants to a Long-term Exercise Intervention
Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of aerobic training on body composition profiles among postmenopausal women with overweight or obesity: a systematic review and dose-response meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Optimal exercise dose on Body Mass Index (BMI) in children and adolescents with overweight and obesity: a systematic review and bayesian model-based network meta-analysis.BMC public health · 2025Pooled it
- Digital technology empowers exercise health management in older adults: a systematic review and meta-analysis of the effects of mHealth-based interventions on physical activity and body composition in older adults.Frontiers in public health · 2025Pooled it
- Changes in 24-h energy expenditure, substrate oxidation, and body composition following resistance exercise and a high protein diet via whey protein supplementation in healthy older men.Physiological reports · 2022Trial
- Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Behavioral Domains and Physiological Characteristics in Young Adults: Findings from Integrated Seven-Day Self-Monitoring and Physiological Assessment.Life (Basel, Switzerland) · 2026Article
- Anti-inflammatory agents in atherosclerosis-and a need for reform: Extraordinary claims require extraordinary evidence.Journal of internal medicine · 2026Article
- Validity of energy expenditure from combined accelerometry and heart rate during load carriage in adults with overweight to mild obesity.European journal of applied physiology · 2026Article
- Longitudinal and cross-sectional evidence that daily resting and activity energy expenditures are independent in humans.The Journal of physiology · 2026Article
- Exogenous lactate infusion enhanced VMH neuroplasticity and visceral fat reduction via PGC-1α-ERα pathway in female rats.European journal of applied physiology · 2026Article
- Trends and Disparities in Obesity-Related Mortality Among U.S. Adults: A CDC WONDER Analysis (1968-2025).Obesity science & practice · 2026Article
- Multilevel metabolic adaptation to exercise training.Communications medicine · 2026Article
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
- Why did Bob stop losing weight? We need to talk about energy expenditure compensation.Biology letters · 2025Article
- Influence of 8-week endurance training on resting energy expenditure and body composition in women.Physiological reports · 2025Article
- Low- or No-Energy Sweeteners and Body Weight Management: Dissecting a "Minor" Effect.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Energy expenditure and obesity across the economic spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chrononutrition and Energy Balance: How Meal Timing and Circadian Rhythms Shape Weight Regulation and Metabolic Health.Nutrients · 2025Review
- Scarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in mice.Obesity (Silver Spring, Md.) · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
85 authors.
Vincent CareauDepartment of Biology, University of Ottawa, Ottawa, ON, Canada. Electronic address: vcareau@uottawa.ca.
Lewis G HalseySchool of Life and Health Sciences, University of Roehampton, London, UK. Electronic address: l.halsey@roehampton.ac.uk.
Herman PontzerEvolutionary Anthropology, Duke University, Durham, NC, USA; Duke Global Health Institute, Duke University, Durham, NC, USA. Electronic address: herman.pontzer@duke.edu.
Philip N AinslieResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Lene F AndersenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Liam J AndersonUniversity of Birmingham, Birmingham, UK.
Lenore ArabDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Issad BaddouUnité Mixte de Recherche en Nutrition et Alimentation, CNESTEN, Université Ibn Tofail URAC39, Regional Designated Center of Nutrition Associated with AFRA/IAEA, Kénitra, Morocco.
Kweku Bedu-AddoDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ellen E BlaakMaastricht University, Maastricht, the Netherlands.
Stephane BlancNutritional Sciences, University of Georgia, Athens, GA, USA; Institut Pluridisciplinaire Hubert Curien, CNRS Université de Strasbourg, Strasbourg UMR7178, France.
Alberto G BonomiPhillips Research, Eindhoven, the Netherlands.
Carlijn V C BoutenDepartment of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.
Maciej S BuchowskiDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Nancy F ButteDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
Stefan G J A CampsMaastricht University, Maastricht, the Netherlands.
Graeme L CloseResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Jamie A CooperNutritional Sciences, University of Georgia, Athens, GA, USA.
Sai Krupa DasJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
Richard CooperDepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA.
Lara R DugasDepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA; Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Simon D EatonDevelopmental Biology & Cancer Department, University College London, London, UK.
Ulf EkelundDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Sonja EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, Germany; University of California, Irvine, Irvine, CA, USA.
Terrence ForresterSolutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica.
Barry W FudgeUniversity of Glasgow, Glasgow, UK.
Annelies H GorisMaastricht University, Maastricht, the Netherlands.
Michael GurvenDepartment of Anthropology, University of California, Santa Barbara, Santa Barbara, CA, USA.
Catherine HamblyInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
Asmaa El HamdouchiUnité Mixte de Recherche en Nutrition et Alimentation, CNESTEN, Université Ibn Tofail URAC39, Regional Designated Center of Nutrition Associated with AFRA/IAEA, Kénitra, Morocco.
Marije B HoosMaastricht University, Maastricht, the Netherlands.
Sumei HuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Noorjehan JoonasCentral Health Laboratory, Ministry of Health and Wellness, Port Louis, Mauritius.
Annemiek M JoosenMaastricht University, Maastricht, the Netherlands.
Peter KatzmarzykPennington Biomedical Research Center, Baton Rouge, LA, USA.
Kitty P KempenMaastricht University, Maastricht, the Netherlands.
Misaka KimuraNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
William E KrausDepartment of Medicine, Duke University, Durham, NC, USA.
Robert F KushnerNorthwestern University, Chicago, IL, USA.
Estelle V LambertHealth through Physical Activity, Lifestyle and Sport Research Centre (HPALS), FIMS International Collaborating Centre of Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
William R LeonardDepartment of Anthropology, Northwestern University, Evanston, IL, USA.
Nader LessanImperial College London Diabetes Centre, Abu Dhabi, UAE, Imperial College London, London, UK.
Corby K MartinPennington Biomedical Research Center, Baton Rouge, LA, USA.
Anine C MedinDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway; Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, 4630 Kristiansand, Norway.
Erwin P MeijerMaastricht University, Maastricht, the Netherlands.
James C MorehenResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK; The FA Group, Burton-Upon-Trent, Staffordshire, UK.
James P MortonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, USA.
Theresa A NicklasDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
Robert M OjiamboMoi University, Eldoret, Kenya; University of Global Health Equity, Kigali, Rwanda.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki and Obesity Center, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Yannis P PitsiladisUniversity of Brighton, Eastbourne, UK.
Jacob Plange-RhuleDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Guy PlasquiDepartment of Nutrition and Movement Sciences, Maastricht University, Maastricht, the Netherlands.
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, USA.
Roberto A RabinovichUniversity of Edinburgh, Edinburgh, UK.
Susan B RacetteProgram in Physical Therapy and Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
David A RaichlenBiological Sciences and Anthropology, University of Southern California, Los Angeles, CA, USA.
Eric RavussinCentral Health Laboratory, Ministry of Health and Wellness, Port Louis, Mauritius.
John J ReillyUniversity of Strathclyde, Glasgow, Scotland, UK.
Rebecca M ReynoldsCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Susan B RobertsJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
Albertine J SchuitUniversity of Tilburg, Tilburg, the Netherlands.
Anders M SjödinDepartment of Nutrition, Exercise and Sports, Copenhagen University, Copenhagen, Denmark.
Eric SticeStanford University, Stanford, CA, USA.
Samuel S UrlacherDepartment of Anthropology, Baylor University, Waco, TX, USA.
Giulio ValentiMaastricht University, Maastricht, the Netherlands.
Ludo M Van EttenMaastricht University, Maastricht, the Netherlands.
Edgar A Van MilMaastricht University, Maastricht and Lifestyle Medicine Center for Children, Jeroen Bosch Hospital's-Hertogenbosch, Maastricht, the Netherlands.
Jonathan C K WellsPopulation, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
George WilsonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Brian M WoodUniversity of California, Los Angeles, Los Angeles, USA; Max Planck Institute for Evolutionary Anthropology, Department of Human Behavior, Ecology, and Culture, Leipzig, Germany.
Jack YanovskiGrowth and Obesity, Division of Intramural Research, NIH, Bethesda, MD, USA.
Tsukasa YoshidaInstitute for Active Health, Kyoto University of Advanced Science, Kyoto, Japan.
Xueying ZhangInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Alexia J Murphy-AlfordNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.
Cornelia U LoechlNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.
Amy H LukeDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. Electronic address: aluke@luc.edu.
Jennifer RoodPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: jennifer.rood@pbrc.edu.
Hiroyuki SagayamaFaculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan. Electronic address: sagayama.hiroyuki.ka@u.tsukuba.ac.jp.
Dale A SchoellerBiotech Center and Nutritional Sciences, University of Wisconsin, Madison, WI, USA. Electronic address: dschoell@nutrisci.wisc.edu.
William W WongDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA. Electronic address: wwong@bcm.edu.
Yosuke YamadaNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan; Institute for Active Health, Kyoto University of Advanced Science, Kyoto, Japan. Electronic address: yyamada831@gmail.com.
John R SpeakmanCenter for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; Shenzhen Key Laboratory of Metabolic Health, CAS Center of Excellence in Animal Evolution and Genetics, Kunming, China. Electronic address: j.speakman@abdn.ac.uk.
IAEA DLW database group
Funding
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MResearch BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5MCoordinating Center for CALERIEU01AG022132 · NIA · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2002 to 2013
$24.9MPhysiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8MRESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9MNutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3MMetabolic Adaptations to Two Year Caloric RestrictionU01AG020478 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RAVUSSIN, ERIC · 2002 to 2008
$13.4MPennington MoTrPAC Adults - RenewalU01AR071160 · NIAMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RAVUSSIN, ERIC · 2017 to 2024
$11.0MDietary Energy Restriction and Metabolic Aging in HumansU01AG020480 · NIA · TUFTS UNIVERSITY BOSTON · PI ROBERTS, SUSAN B · 2002 to 2008
$8.2MThe Human Life Course and the Biodemography of AgingR01AG024119 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GURVEN, MICHAEL DOUGLAS, KAPLAN, HILLARD S · 2004 to 2015
$7.4MENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGYR33AG070455 · NIA · DUKE UNIVERSITY · PI KIM M. HUFFMAN, WILLIAM E KRAUS · 2021 to 2026
$4.0MIntramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD000641NCATS NIH HHS UL1 TR001414NCCDPHP CDC HHS R01 DP000092NCI NIH HHS R01 CA107545NCI NIH HHS R01 CA119171NCRR NIH HHS S10 RR026764NHLBI NIH HHS R01 HL082988NHLBI NIH HHS T32 HL007633NHLBI NIH HHS U01 HL138638NIAAA NIH HHS L30 AA015010NIAMS NIH HHS U01 AR071160NIA NIH HHS R01 AG024119NIA NIH HHS R01 AG029914NIA NIH HHS R33 AG070455NIA NIH HHS R56 AG067200NIA NIH HHS U01 AG020478NIA NIH HHS U01 AG020480NIA NIH HHS U01 AG022132NICHD NIH HHS R01 HD065825NIDDK NIH HHS K23 DK068052NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK030031NIDDK NIH HHS R01 DK056781NIDDK NIH HHS R01 DK069465NIDDK NIH HHS R01 DK074387NIDDK NIH HHS R01 DK080760NIDDK NIH HHS R01 DK080763NIDDK NIH HHS R01 DK085163NIDDK NIH HHS R21 DK098765NIDDK NIH HHS RC1 DK086881NIDDK NIH HHS UG3 DK128298WHI NIH HHS N01 WH074315
Abstract
Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.
Indexed as
AdiposityObesityEnergy IntakeEnergy MetabolismHumansactivitybasal metabolic ratedaily energy expenditureenergy compensationenergy management modelsexerciseHomo sapienstrade-offsweight loss
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT06923163ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.