ArticleAmerican heart journal2022
Relationship of ejection fraction and natriuretic peptide trajectories in heart failure with baseline reduced and mid-range ejection fraction.
Article in American heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Combined Prognostic Value of Follow-Up Ejection Fraction and Natriuretic Peptide Measurements in Heart Failure With Reduced Ejection Fraction Following Initiation of Pharmacotherapy.Journal of the American Heart Association · 2026Article
- Left Ventricular Ejection Fraction in Heart Failure-A Parameter to Be Discontinued?Journal of clinical medicine · 2026Review
- The Application Value of Brain Natriuretic Peptide in the Prognostic Evaluation of Patients With Chronic Left Heart Failure.Cardiovascular therapeutics · 2025Article
- Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation.Clinical interventions in aging · 2025Article
- Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction.Journal of the American Heart Association · 2024Article
- Left ventricular ejection fraction: clinical, pathophysiological, and technical limitations.Frontiers in cardiovascular medicine · 2024Review
- Noninvasive Electrical Mapping Compared with the Paced QRS Complex for Optimizing CRT Programmed Settings and Predicting Multidimensional Response.Journal of cardiovascular translational research · 2023Article
- Prognostic implications of left ventricular ejection fraction trajectory changes in heart failure.Frontiers in cardiovascular medicine · 2023Article
- Machine learning for multidimensional response and survival after cardiac resynchronization therapy using features from cardiac magnetic resonance.Heart rhythm O2 · 2022Article
- Cardiac magnetic resonance defines mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundThe prognostic importance of trajectories of neurohormones relative to left ventricular function over time in heart failure with reduced and mid-range EF (HFrEF and HFmrEF) is poorly defined.
objectiveTo evaluate left ventricular ejection fraction (LVEF) and B-type natriuretic peptide (BNP) trajectories in HFrEF and HFmrEF.
methodsAnalyses of LVEF and BNP trajectories after incident HF admissions presenting with abnormal LV systolic function were performed using 3 methods: a Cox proportional hazards model with time-varying covariates, a dual longitudinal-survival model with shared random effects, and an unsupervised analysis to capture 3 discrete trajectories for each parameter.
resultsAmong 1,158 patients (68.9 ± 13.0 years, 53.3% female), both time-varying LVEF measurements (P=.001) and log-transformed BNP measurements (p-values=2 × 10
conclusionAlthough LVEF trajectories have greater temporal variation, BNP trajectories provide additive prognostication and an even stronger association with survival times in heart failure patients with abnormal LV systolic function.
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