ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2022
Worldwide time trends in prevalence of symptoms of rhinoconjunctivitis in children: Global Asthma Network Phase I.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Clinical Practice Guideline: Immunotherapy for Inhalant Allergy.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Guideline
- Reported Symptoms Upon Exposure to Aeroallergen Highly Predict Allergen Sensitization Among 12-Year-Old Children.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Prevalence and characteristics of allergic disease among pediatric patients of urban, rural, and remote primary care clinics: A multisite study in the Philippines.Asia Pacific allergy · 2026Article
- Early-life microRNA signatures in cord blood associated with allergic rhinitis and asthma development.The Journal of allergy and clinical immunology · 2025Article
- Incidence and Prevalence of Childhood Atopic Diseases in Dutch Primary Care.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Subcutaneous House Dust Mite Immunotherapy Effectiveness and Safety in a Paediatric Population: A Prospective Real-Life Study.Journal of clinical medicine · 2025Article
- Correlation between dietary calcium intake and eczema in American adult population.Scientific reports · 2024Article
- Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis.BMC microbiology · 2024Article
- Executive Summary of Clinical Practice Guideline on Immunotherapy for Inhalant Allergy.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Article
- National Trends and Prevalence of Atopic Dermatitis and Pandemic-Related Factors among Korean Adults, 2007-2021.International archives of allergy and immunology · 2024Article
- Allergen-specific sublingual immunotherapy altered gut microbiota in patients with allergic rhinitis.Frontiers in cellular and infection microbiology · 2024Article
- Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back.Frontiers in allergy · 2024Article
- Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017.The journal of allergy and clinical immunology. Global · 2023Article
- Prevalence, severity, and risk factors of allergic rhinitis among schoolchildren in Saudi Arabia: A national cross-sectional study, 2019.The World Allergy Organization journal · 2023Article
- The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort.International journal of epidemiology · 2023Article
- Update meta-analysis on the efficacy and safety issues of fexofenadine.The World Allergy Organization journal · 2023Article
- Early inhalant allergen sensitization at component level: an analysis in atopic Dutch children.Frontiers in allergy · 2023Article
- High baseline prevalence of atopic comorbidities and medication use in children treated with allergy immunotherapy in the REAl-world effeCtiveness in allergy immunoTherapy (REACT) study.Frontiers in pediatrics · 2023Article
- The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study.The European respiratory journal · 2022Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 7 countries.
Funding
Abstract
backgroundThe Global Asthma Network (GAN), by using the International Study of Asthma and Allergies in Childhood (ISAAC) methodology, has updated trends in prevalence of symptoms of childhood allergic diseases, including non-infective rhinitis and conjunctivitis ('rhinoconjunctivitis'), which is reported here.
methodsPrevalence and severity of rhinoconjunctivitis were assessed by questionnaire among schoolchildren in GAN Phase I and ISAAC Phase I and III surveys 15-23 years apart. Absolute rates of change in prevalence were estimated for each centre and modelled by multi-level linear regression to compare trends by age group, time period and per capita national income.
resultsTwenty-seven GAN centres in 14 countries surveyed 74,361 13- to 14-year-olds ('adolescents') and 45,434 6- to 7-year-olds ('children'), with average response proportions of 90% and 79%, respectively. Many centres showed highly significant (p < .001) changes in prevalence of rhinoconjunctivitis in the past year ('current rhinoconjunctivitis') compared with ISAAC. The direction and magnitude of centre-level trends varied significantly (p < .001) both within and between countries. Overall, current rhinoconjunctivitis prevalence decreased slightly from ISAAC Phase III to GAN: -1.32% per 10 years, 95% CI [-2.93%, +0.30%] among adolescents; and -0.44% [-1.29%, +0.42%] among children. Together, these differed significantly (p < .001) from the upward trend within ISAAC. Among adolescents, centre-level trends in current rhinoconjunctivitis were highly correlated with those for eczema symptoms (rho = 0.72, p < .0001) but not with centre-level trends in asthma symptoms (rho = 0.15, p = .48). Among children, these correlations were positive but not significant.
conclusionSymptoms of non-infective rhinoconjunctivitis among schoolchildren may no longer be on the increase globally, although trends vary substantially within and between countries.
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