Testing the Phenotypic Effects of a Rab Chimera that Resolves Exchange Factor Specificity from Effector Specificity.

Hua Yuan, Peter Novick

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 84% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hua YuanDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.

Peter NovickDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA. pnovick@ucsd.edu.

University of California, San Diego · US

Funding

Coordination of membrane traffic through rab GEF and GAP cascadesR01GM082861 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOVICK, PETER JAY · 2008 to 2020

$4.4M

NIGMS NIH HHS R01 GM082861

6 · The paper itself

Abstract

Rab GTPases play key roles in defining the identity of the various compartments that comprise the secretory and endocytic pathways. Recruitment of a Rab to a specific compartment requires its localized activation by a guanine nucleotide exchange factor (GEF). This in turn results in the recruitment of a distinct set of Rab effectors that directs the recognition of the appropriate target compartment by a carrier vesicle and their subsequent fusion. A chimeric Rab protein, Ypt1-SW1

Indexed as

Guanine Nucleotide Exchange Factorsrab GTP-Binding ProteinsR-SNARE ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsGuanine Nucleotide Exchange Factorsrab GTP-Binding ProteinsR-SNARE ProteinsSaccharomyces cerevisiae ProteinsSNC1 protein, S cerevisiaeUSO1 protein, S cerevisiaeVesicular Transport ProteinsYPT1 protein, S cerevisiaeBgl2Rab effectorRab GEFRab GTPaseSnc1Uso1Ypt1Ypt1-SW1Sec4

Identifiers

PMID34453710

DOI10.1016/j.molcel.2007.01.013

OpenAlexW3193397820

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.