Evidence map›Paper›PMID 34453679›Full record

ArticleEnvironmental science and pollution research international2022

Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia.

Yared Beyene Yohannes, Shouta M M Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Hokuto Nakata, Kaampwe Muzandu, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  5. Review
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  9. Mapping and Identifying Candidate Genes Enabling Cadmium Accumulation inInternational journal of molecular sciences · 2023
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  11. A novel mushroom (Frontiers in nutrition · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 6 countries.

Yared Beyene Yohannes *Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan.
Shouta M M Nakayama *Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan. shouta-nakayama@vetmed.hokudai.ac.jp.ORCID http://orcid.org/0000-0003-1635-2898
John YabeSchool of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka, Zambia.
Haruya ToyomakiLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan.
Andrew KatabaLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan.
Hokuto NakataLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan.
Kaampwe MuzanduSchool of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka, Zambia.
Yoshinori IkenakaLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan.
Kennedy ChoongoSchool of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka, Zambia.
Mayumi IshizukaLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan. ishizum@vetmed.hokudai.ac.jp.
Hokkaido University · JPUniversity of Zambia · ZMSapporo University · JPUniversity of Namibia · NA

Funding

hokkaido university SOUSEI Support Program for Young Researchers in FY2020hokkaido university Specific Research Projectsjapan prize foundation NAjapan science and technology agency JPMXS0420100619japan science and technology agency No. JPMJAS2001japan society for the promotion of science CORE to CORE programjapan society for the promotion of science JPJSBP120209902ministry of education, culture, sports, science and technology 18H0413208ministry of education, culture, sports, science and technology No. 16H0177906, 18K1984708, 18KK028708, 21H02351ministry of education, culture, sports, science and technology No. 17KK0009 and 20K20633science and technology research partnership for sustainable development No. JPMJSA1501
6 · The paper itself

Abstract

Interindividual genetic variations determine human's susceptibility to heavy metal-induced toxicity. Thus, we analyzed blood concentrations of lead (Pb) and cadmium (Cd) in 140 lead-exposed children. Genotyping of the glutathione S-transferase (GST) genes, GSTM1, GSTT1, and GSTP1 genes, was carried out to investigate their possible association with heavy metal concentrations and the risk of susceptibility to Pb toxicity. Exposure to both heavy metals was prevalent among the children. The blood Pb level ranged from 3.30 to 74.0 μg dL

Indexed as

CadmiumLeadCase-Control StudiesChildGenotypeGlutathione TransferaseHumansMiningPolymorphism, GeneticRisk FactorsZambiaZincCadmiumGlutathione TransferaseLeadZincBloodCadmiumChildrenGSTKabweLeadPolymorphism

Identifiers

PMID34453679
OpenAlexW3194795753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.