Evidence map›Paper›PMID 34453654›Full record

ArticleThe international journal of cardiovascular imaging2022

The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon.

Gonul Aciksari, Gokhan Cetinkal, Mehmet Kocak, Adem Atici, Fatma Betul Celik, Mustafa Caliskan

Abstract read
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In one paragraph

Article in The international journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  4. Identification of potential biomarkers for coronary slow flow using untargeted metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gonul AciksariDepartment of Cardiology, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. drgonulkutlu@hotmail.com.ORCID http://orcid.org/0000-0002-8380-3065
Gokhan CetinkalDepartment of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-5291-0645
Mehmet KocakDepartment of Emergency Medicine, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-0782-390X
Adem AticiDepartment of Cardiology, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-6580-7954
Fatma Betul CelikDepartment of Cardiology, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-4472-4847
Mustafa CaliskanDepartment of Cardiology, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-7417-4001
Istanbul Medeniyet University · TRFatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi · TRŞişli Etfal Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow flow phenomenon (CSFP) in patients undergoing elective coronary angiography for suspected coronary artery disease. This prospective study included a total of 84 CSFP patients and 83 controls with normal coronary flow, as evidenced by coronary angiography. The Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was used to measure the coronary blood flow velocity. The lipid profiles were analyzed and TG/HDL-C ratio were calculated dividing absolute TG levels by absolute HDL-C levels in peripheral blood. The median TG/HDL-C ratio was higher in the CSFP group than the control group (3.4 [2.6 to 4.9] vs. 2.3 [1.8 to 3], respectively; p < 0.001). The multivariate logistic regression analysis revealed that TG/HDL-C ratio was an independent predictor of CSFP (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.59-2.32; p = 0.001) and TG/HDL-C ratio was positively correlated with the TFC in the CSFP group (r = 0.311, p < 0.001). The area under the receiver operating characteristic curve of TG/HDL-C for the diagnosis of CSFP was 0.73 (95% CI 0.65-0.81; p < 0.001). If a cut-off value of 2.75 was used, higher levels of TG/HDL-C ratio could predict the presence of CSFP with 72% sensitivity and 71% specificity. Our study results suggest that TG/HDL-C ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity.

Indexed as

No-Reflow PhenomenonCholesterol, HDLCoronary AngiographyCoronary Artery DiseaseHumansPredictive Value of TestsProspective StudiesTriglyceridesCholesterol, HDLTriglyceridesCoronary slow-flow phenomenonThrombolysis in Myocardial Infarction frame countTriglyceride/high-density lipoprotein cholesterol ratio

Identifiers

PMID34453654
OpenAlexW3162063228

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.