Evidence map›Paper›PMID 34453602›Full record

ArticlePediatric nephrology (Berlin, Germany)2022

IgA-dominant infection-associated glomerulonephritis in the pediatric population.

Daniel S Grosser, Paul Persad, Romualdo V Talento, Lawrence R Shoemaker, Tracy E Hunley, Guillermo Hidalgo, Mihail M Subtirelu, Susan Coventry, Radhakrishna Baliga, Agnes B Fogo

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Guideline
  2. International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Daniel S GrosserDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center At San Antonio, San Antonio, TX, USA. grosser@uthscsa.edu.
Paul PersadLaboratory for Kidney Pathology, Nashville, TN, USA.
Romualdo V TalentoEastern Carolina Pathology, Wilson, NC, USA.
Lawrence R ShoemakerDepartment of Pediatrics, Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL, USA.
Tracy E HunleyDivision of Pediatric Nephrology, Monroe Carell Jr Children's Hospital At Vanderbilt, Nashville, TN, USA.
Guillermo HidalgoPediatric Nephrology, East Carolina University, Greenville, NC, USA.
Mihail M SubtireluPediatric Nephrology and Hypertension, East Tennessee Children's Hospital, Knoxville, TN, USA.
Susan CoventryDepartment of Pathology, Norton Children's Hospital, Louisville, KY, USA.
Radhakrishna BaligaTulane University School of Medicine, New Orleans, LA, USA.
Agnes B FogoDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
East Tennessee Children's Hospital · USFlorida College · USHackensack Meridian Health · USKosair Children's Hospital · USMonroe Carell Jr. Children's Hospital · USThe University of Texas Health Science Center at San Antonio · USTulane University · USVanderbilt University Medical Center · USWilson Community College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIgA-dominant infection-associated glomerulonephritis is well-documented in adults but has not been studied in depth in children. We assessed the incidence of pediatric IgA-dominant infection-associated glomerulonephritis and clinical and kidney biopsy findings.

methodsPediatric native kidney biopsies over a 10-year period with IgA dominance, strong C3, and findings indicative of infection-associated etiology were identified.

resultsWe identified 9 cases of IgA-dominant infection-associated glomerulonephritis, 0.8% of pediatric native kidney biopsies. Seven patients presented with elevated creatinine. All had hematuria and proteinuria. Eight patients had clinical evidence of infection: one each with central port infection by methicillin-sensitive Staphylococcus aureus, recurrent streptococcal pharyngitis and recent otitis media, streptococcal pharyngitis demonstrated 8 months after biopsy, suspected streptococcal scalded skin syndrome, and viral gastroenteritis, and three with serologic evidence of Streptococcal infection but no identified site of infection. All but one patient experienced short-term normalization of creatinine and resolution of proteinuria, though two eventually progressed to kidney failure: one 3 years later due to progressive disease and one 11 years later due to focal segmental glomerulosclerosis without concurrent immune deposits.

conclusionsPediatric IgA-dominant infection-associated glomerulonephritis is rare, and generally has a favorable prognosis, contrasting that seen in adults with severe comorbidities. A higher resolution version of the Graphical abstract is available as Supplementary.

Indexed as

GlomerulonephritisGlomerulonephritis, IGAPharyngitisAdultChildCreatinineFemaleHumansImmunoglobulin AMaleProteinuriaCreatinineImmunoglobulin AGlomerulonephritisIgA-dominantInfection-associatedPediatric

Identifiers

PMID34453602
OpenAlexW3194307658

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.