Evidence map›Paper›PMID 34453590›Full record

ArticlePediatric surgery international2021

Urinary N

Kazuki Yokota, Akinari Hinoki, Kyoko Hiramatsu, Hizuru Amano, Machiko Kawamura, Yachiyo Kuwatsuka, Takahisa Tainaka, Chiyoe Shirota, Wataru Sumida, Satoshi Makita and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric surgery international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. A Novel Polyamine Oxidase fromBiotech (Basel (Switzerland)) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Kazuki YokotaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Akinari HinokiDepartment of Rare/Refractory Cancer Analysis Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kyoko HiramatsuStem Cell Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hizuru AmanoDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Machiko KawamuraDepartment of Hematology, Saitama Cancer Center, Saitama, Japan.
Yachiyo KuwatsukaCenter for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahisa TainakaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Chiyoe ShirotaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Wataru SumidaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Satoshi MakitaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Masamune OkamotoDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Aitaro TakimotoDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Akihiro YasuiDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Yoichi NakagawaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.
Hiroo UchidaDepartment of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan. hiro2013@med.nagoya-u.ac.jp.
Masao KawakitaStem Cell Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Nagoya University · JPTokyo Metropolitan Institute of Medical Science · JPTokyo Metropolitan Komagome Hospital · JP

Funding

Grant-in-Aid for Scientific Research (C) 16K08957
6 · The paper itself

Abstract

purposeMinimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N

methodsUrinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared.

resultsA total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%).

conclusionThe urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.

Indexed as

NeoplasmsSpermineAdultAgedBiomarkers, TumorCase-Control StudiesChildHumansBiomarkers, TumorN',N''-diacetylspermineSpermineMalignant lymphomaN1,N12-diacetylsperminePediatric cancerPolyamineUrinary tumor marker

Identifiers

PMID34453590
OpenAlexW3195432190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.