Evidence map›Paper›PMID 34453577›Full record

ReviewClinical research in cardiology : official journal of the German Cardiac Society2021

Echocardiography-derived total atrial conduction time (PA-TDI duration): risk stratification and guidance in atrial fibrillation management.

Patrick Müller, Bob Weijs, Nadine M A A Bemelmans, Andreas Mügge, Lars Eckardt, Harry J G M Crijns, Jeroen J Bax, Dominik Linz, Dennis W den Uijl

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Association of P-Wave Parameters With Left Atrial Hemodynamics in Atrial Cardiomyopathy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Total atrial conduction time predicts new-onset atrial fibrillation in patients with transthyretin amyloid cardiomyopathy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Dynamic change in maternal cardiac function during pregnancy.Frontiers in cardiovascular medicine · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Left Atrial Cardiomyopathy - A Challenging Diagnosis.Frontiers in cardiovascular medicine · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Patrick MüllerDepartment of Cardiology II-Electrophysiology, University Hospital of Münster, 48149, Münster, Germany. mueller.patr@googlemail.com.ORCID http://orcid.org/0000-0003-1641-5449
Bob WeijsDepartment of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+, Maastricht, The Netherlands.
Nadine M A A BemelmansDepartment of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+, Maastricht, The Netherlands.
Andreas MüggeCardiovascular Center, St. Josef Hospital Bochum, Ruhr-University Bochum, Bochum, Germany.
Lars EckardtDepartment of Cardiology II-Electrophysiology, University Hospital of Münster, 48149, Münster, Germany.
Harry J G M CrijnsDepartment of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+, Maastricht, The Netherlands.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Dominik LinzDepartment of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+, Maastricht, The Netherlands.
Dennis W den UijlDepartment of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+, Maastricht, The Netherlands.
Maastricht University · NLUniversity Hospital Münster · DELeiden University Medical Center · NLSt. Josef-Hospital · DEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is a major cause of cardiovascular morbidity and mortality. To early detect and to avoid AF-related complications, several cardiac imaging modalities and approaches aim to quantify the severity of the underlying atrial cardiomyopathy (i.e., the extent of atrial remodeling). However, most established cardiac imaging modalities just incorporate single components of atrial remodeling and do not reflect the complete multifactorial process, which may contribute to their limited predictive value. Echocardiography-derived PA-TDI duration is a sophisticated echocardiographic parameter to assess total atrial conduction time and directly reflects both electrical and structural changes to the atria. Therefore, PA-TDI duration provides a more comprehensive quantification of the extent of atrial remodeling than other imaging modalities. In this article we review the role of PA-TDI duration as a marker of atrial remodeling and summarize the available data on PA-TDI duration to identify patients at risk for AF, as well as to guide AF management. Moreover, we discuss how to assess PA-TDI duration and provide recommendations on the implementation of PA-TDI duration into routine clinical care.

Indexed as

Atrial FibrillationAtrial RemodelingEchocardiography, DopplerGlobal HealthHeart AtriaHeart RateHumansMorbidityRisk AssessmentSurvival RateAtrial fibrillationPA-TDI durationTotal atrial conduction time

Identifiers

PMID34453577
PMCPMC8563556
OpenAlexW3194997177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.