Evidence map›Paper›PMID 34453566›Full record

ReviewCell and tissue research2021

Parietal epithelial cell dysfunction in crescentic glomerulonephritis.

Milagros N Wong, Pierre-Louis Tharaux, Florian Grahammer, Victor G Puelles

Open access · hybridAbstract readReview
In one paragraph

Review in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Milagros N WongIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Pierre-Louis TharauxIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-6062-5905
Florian Grahammer *III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. f.grahammer@uke.de.
Victor G Puelles *III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. v.puelles@uke.de.ORCID http://orcid.org/0000-0002-7735-5462
Universität Hamburg · DEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.

Indexed as

AnimalsEpithelial CellsGlomerulonephritisHumansKidney GlomerulusCrescentic glomerulonephritisImmune systemParietal cell activationParietal epithelial cellsPodocyte gain

Identifiers

PMID34453566
PMCPMC8523405
OpenAlexW3195985592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.