Evidence map›Paper›PMID 34453548›Full record

ReviewThe Journal of infectious diseases2021

Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework.

Zoe A Dyson, Kathryn E Holt

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Azithromycin-resistantJAC-antimicrobial resistance · 2026
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  11. Comparative genomics ofVirulence · 2025
    Article
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  14. Article
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  17. Emergence of carbapenem-resistantFrontiers in microbiology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zoe A DysonLondon School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-8887-3492
Kathryn E HoltLondon School of Hygiene & Tropical Medicine, London, United Kingdom.

Funding

Wellcome TrustWellcome Trust 106158/Z/14/Z
6 · The paper itself

Abstract

In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically important subpopulations, which require the definition of new genotypes and extension of associated software to facilitate the detection of antimicrobial resistance (AMR) mutations. Analysis of 4632 WGS provide an updated overview of the global S Typhi population structure and genotyping framework, revealing the widespread nature of haplotype 58 ([H58] 4.3.1) genotypes and the diverse range of genotypes carrying AMR mutations.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialGenotypeHaplotypesHumansPhylogenyPolymorphism, Single NucleotideSalmonella typhiTyphoid FeverWhole Genome SequencingAnti-Bacterial AgentsAMRpathogen genotypingSalmonella Typhityphoid feverWGS

Identifiers

PMID34453548
PMCPMC8687072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.