ArticleBrain and behavior2021
Effects of transcranial magnetic stimulation on anhedonia in treatment resistant major depressive disorder.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Examining the relationship between pre-treatment anhedonia and treatment outcomes in individuals with anxiety or depression: A systematic review.Journal of affective disorders · 2026Pooled it
- Noninvasive Brain Stimulation over the Frontopolar Cortex Promotes Willingness to Exert Cognitive Effort in a Foraging-Like Sequential Choice Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Effect of DLPFC rTMS on anhedonia and alpha asymmetry in depressed patients.Scientific reports · 2025Trial
- Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression-A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2023Trial
- Reward pursuit during a translational reward task correlates with anhedonia reductions following rTMS in patients with major depressive disorder.Translational psychiatry · 2026Article
- Anticipatory pleasure as a key hedonic component in classifying major depressive disorder: multidimensional behavioral evidence from majority vote algorithm.BMC psychiatry · 2026Article
- EEG Microstate Alterations in Anhedonia Subtypes of Major Depressive Disorder and Their Modulation by Intermittent Theta-Burst Stimulation.Depression and anxiety · 2026Article
- An examination of anhedonia as a predictor of response with transcranial magnetic stimulation treatment for youth with depression.Journal of mood and anxiety disorders · 2025Article
- Association between anhedonia severity and clinical, humanistic, and economic outcomes among US adults with major depressive disorder.The international journal of neuropsychopharmacology · 2025Article
- Digital phenotyping evidence for the reduced positivity offset as a mechanism underlying anhedonia among individuals at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Anhedonia: Current and future treatments.PCN reports : psychiatry and clinical neurosciences · 2025Review
- Consensus review and considerations on TMS to treat depression: A comprehensive update endorsed by the National Network of Depression Centers, the Clinical TMS Society, and the International Federation of Clinical Neurophysiology.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Review
- Evaluating state-based network dynamics in anhedonia.Neuroimage. Reports · 2024Article
- Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program.Journal of mood and anxiety disorders · 2024Article
- Review
- Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Article
- Anhedonia and Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Review
- Therapeutic Potential of Vortioxetine for Anhedonia-Like Symptoms in Depression: A Post Hoc Analysis of Data from a Clinical Trial Conducted in Japan.Neuropsychiatric disease and treatment · 2022Article
- Circuit-Targeted Neuromodulation for Anhedonia.Current topics in behavioral neurosciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnhedonia is one of the defining features of depression but it remains difficult to target and treat. Transcranial magnetic stimulation (TMS) is a proven treatment for depression, but its effects on anhedonia and whether anhedonia can be used as a predictive biomarker of response is not well known.
methodsSnaith-Hamilton Pleasure Scale was administered to patients with depression before and after a standard course of TMS in a naturalistic outpatient setting.
results144 patients were analyzed. There was an overall significant improvement in anhedonia from pre- to post-treatment (7.69 ± 3.88 vs. 2.96 ± 3.45; p < .001). Significant correlations between improvements in anhedonia and other depressive symptoms were present (r = 0.55, p < .001). Logistic regression revealed that baseline anhedonia severity was not a significant predictor of clinical outcome.
conclusionThis is the first large, naturalistic study examining the effects of standard, non-research TMS on anhedonia. Among depressed patients, TMS resulted in significant improvements in anhedonia. Patients with severe baseline anhedonia had an equal chance of achieving clinical response/remission. Patients with anhedonia should not be excluded from treatment if they are safe for outpatient care and otherwise appropriate candidates for treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.