ArticleWorld journal of pediatrics : WJP2021
Molecular epidemiology of coxsackievirus A16 circulating in children in Beijing, China from 2010 to 2019.
Article in World journal of pediatrics : WJP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Targeted sequence capture of coxsackievirus A6 using nanopore sequencing directly from clinical specimens.Microbiology spectrum · 2026Article
- Molecular characterization and whole-genome sequencing-based genetic evolution of coxsackievirus A16 in Taiyuan City, 2023-2025.Archives of virology · 2026Article
- Article
- Spatiotemporal dynamics and genotypic shift of Coxsackievirus A16 in Fujian, China, from 2010 to 2025.Frontiers in microbiology · 2026Article
- Article
- First Report of Hand, Foot, and Mouth Disease (HFMD) Outbreak in the West Bank, Palestine: Molecular Characterization of Coxsackievirus A16 (CV-A16).The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Characteristics of CVA16 B1c strains isolated for the first time in the Heilongjiang Province of China.Frontiers in microbiology · 2025Article
- The genetic and proliferation characterization analysis of novel coxsackievirus A12 in Beijing, China.Frontiers in microbiology · 2025Article
- Epidemiology and genetic characteristics of coxsackievirus A16 associated with hand-foot-mouth disease in Hangzhou city, Zhejiang province from 2021 to 2024.Frontiers in microbiology · 2025Article
- Effectiveness of EV-A71 Vaccine and Its Impact on the Incidence of Hand, Foot and Mouth Disease: A Systematic Review.Vaccines · 2024Review
- Circulating trends of hand, foot, and mouth disease in Hubei Province, China: Impact from the COVID-19 pandemic.Heliyon · 2023Article
- Current status of hand-foot-and-mouth disease.Journal of biomedical science · 2023Review
- Exploring the influence of COVID-19 on the spread of hand, foot, and mouth disease with an automatic machine learning prediction model.Environmental science and pollution research international · 2023Article
- Surveillance, epidemiology, and impact of the coronavirus disease 2019 interventions on the incidence of enterovirus infections in Nanchang, China, 2010-2022.Frontiers in microbiology · 2023Article
- Epidemiological characteristics and spatiotemporal patterns of hand, foot, and mouth disease in Hubei, China from 2009 to 2019.PloS one · 2023Article
- Multiple molecular characteristics of circulating enterovirus types among pediatric hand, foot and mouth disease patients after EV71 vaccination campaign in Wuxi, China.Epidemiology and infection · 2022Article
- Genetic characterization and molecular epidemiology of Coxsackievirus A12 from mainland China during 2010-2019.Frontiers in microbiology · 2022Article
- Molecular Epidemiology of Herpangina Children in Tongzhou District, Beijing, China, During 2019-2020.Frontiers in medicine · 2022Article
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12 authors.
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Abstract
backgroundCoxsackievirus A16 (CVA16) is one of the major etiological agents of hand, foot and mouth disease (HFMD). This study aimed to investigate the molecular epidemiology and evolutionary characteristics of CVA16.
methodsThroat swabs were collected from children with HFMD and suspected HFMD during 2010-2019. Enteroviruses (EVs) were detected and typed by real-time reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR. The genotype, evolutionary rate, the most recent common ancestor, population dynamics and selection pressure of CVA16 were analyzed based on viral protein gene (VP1) by bioinformatics software.
resultsA total of 4709 throat swabs were screened. EVs were detected in 3180 samples and 814 were CVA16 positive. More than 81% of CVA16-positive children were under 5 years old. The prevalence of CVA16 showed obvious periodic fluctuations with a high level during 2010-2012 followed by an apparent decline during 2013-2017. However, the activities of CVA16 increased gradually during 2018-2019. All the Beijing CVA16 strains belonged to sub-genotype B1, and B1b was the dominant strain. One B1c strain was detected in Beijing for the first time in 2016. The estimated mean evolutionary rate of VP1 gene was 4.49 × 10
conclusionsThe dominant strains of CVA16 belonged to clade B1b and evolved in a fast evolutionary rate during 2010-2019 in Beijing. To provide more favorable data for HFMD prevention and control, it is necessary to keep attention on molecular epidemiological and evolutionary characteristics of CVA16.
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