Evidence map›Paper›PMID 34453218›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2021

Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids.

Tatsiana V Petrasheuskaya, Debora Wernitznig, Márton A Kiss, Nóra V May, Dominik Wenisch, Bernhard K Keppler, Éva Frank, Éva A Enyedy

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tatsiana V PetrasheuskayaDepartment of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, 6720, Hungary.
Debora WernitznigInstitute of Inorganic Chemistry and Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Währinger Straße 42, Vienna, Austria.
Márton A KissDepartment of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, 6720, Hungary.
Nóra V MayCentre for Structural Science, Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, 1117, Hungary.
Dominik WenischInstitute of Inorganic Chemistry and Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Währinger Straße 42, Vienna, Austria.
Bernhard K KepplerInstitute of Inorganic Chemistry and Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Währinger Straße 42, Vienna, Austria.
Éva FrankDepartment of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, 6720, Hungary.
Éva A EnyedyDepartment of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, 6720, Hungary. enyedy@chem.u-szeged.hu.ORCID 0000-0002-8058-8128
University of Szeged · HUUniversity of Vienna · ATHUN-REN Research Centre for Natural Sciences · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The terminal N-mono- and dimethylated derivatives of an estrone-salicylaldehyde thiosemicarbazone hybrid and their highly cytotoxic Cu(II) complexes were synthesized and characterized in addition to their structurally related simpler bicyclic analogues. Solution stability and structure of the complexes were determined by UV-visible spectrophotometry and electron paramagnetic resonance spectroscopy. The monomethylation has a minor influence on the pK

Indexed as

Antineoplastic AgentsCoordination ComplexesNeoplasmsThiosemicarbazonesAldehydesCopperCrystallography, X-RayEstroneHumansLigandsAldehydesAntineoplastic AgentsCoordination ComplexesCopperEstroneLigandssalicylaldehydesalicylaldehyde thiosemicarbazoneThiosemicarbazones3D spheroidsCaspase-dependenceCytotoxicitySpeciationSterane hybrids

Identifiers

PMID34453218
OpenAlexW3194948526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.