ArticleNeuroradiology2022
Gray matter volume reduction with different disease duration in trigeminal neuralgia.
Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pooled it
- Mapping global research landscape and trends in magnetic resonance imaging applications for primary trigeminal neuralgia: a bibliometric analysis.Neurosurgical review · 2025Review
- Structural alterations in occipital cortices in trigeminal neuralgia: a voxel- and surface-based morphometric MRI study.The journal of headache and pain · 2025Article
- Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia.Scientific reports · 2025Article
- Thalamic changes in patients with chronic facial pain.Neuroradiology · 2025Article
- Altered trends of local brain function in classical trigeminal neuralgia patients after a single trigger pain.BMC medical imaging · 2024Article
- A multimodal meta-analysis of gray matter alterations in trigeminal neuralgia.Frontiers in neurology · 2023Review
- Deficits in the thalamocortical pathway associated with hypersensitivity to pain in patients with frozen shoulder.Frontiers in neurology · 2023Article
- The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role ofInternational journal of environmental research and public health · 2022Review
- Structural and Functional Brain Changes in Patients With Classic Trigeminal Neuralgia: A Combination of Voxel-Based Morphometry and Resting-State Functional MRI Study.Frontiers in neuroscience · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStructural magnetic resonance imaging is widely used to explore brain gray and white matter structure in trigeminal neuralgia (TN) but has yielded conflicting findings. This study investigated the relationship between disease duration as a clinical feature of TN and changes in brain structure.
methodsWe divided 49 TN patients into three groups (TN1-TN3) based on disease duration (TN1 = 1.1 ± 0.7 (0-2) years, TN2 = 4.8 ± 1.5 (3-7) years, TN3 = 15.1 ± 5.5 (10-30) years). We used voxel-based morphometry (VBM) to compare the gray matter volume (GMV) across groups and between TN patients and 18 matched healthy control subjects.
resultsThe TN1 group showed reduced GMV of pain-related regions in the cerebellum; the TN2 group showed reduced GMV in the thalamus and the motor/sensory cortex; and the TN3 group showed reduced GMV in the emotional and reward circuits compared with healthy controls. Similar brain regions, including bilateral hippocampi, caudate, left insular cortex, and medial superior frontal cortex, were affected in TN2 and TN3 compared with TN1.
conclusionDisease duration can explain differences in structural alterations-especially in pain-related brain regions-in TN. These results highlight the advanced structural neuroimaging method that are valuable tools to assess the trigeminal system in TN and may further our current understanding of TN pathology.
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