ReviewNature reviews. Neuroscience2021
The grid code for ordered experience.
Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Article
- Spaces and sequences in the hippocampus: a homological perspective.Journal of computational neuroscience · 2026Article
- The Primate Hippocampus Constructs a Temporal Scaffold Anchored to Behavioral Events.bioRxiv : the preprint server for biology · 2025Article
- Cognitive Maps in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Uncovering the Role of the Human Hippocampus in Procedural Motor Learning: Insights from Implicit Sensorimotor Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Task-relevant representational spaces in human memory traces.PLoS computational biology · 2025Article
- Reconciling flexibility and efficiency: medial entorhinal cortex represents a compositional cognitive map.Nature communications · 2025Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- Goal-directed navigation in humans and deep reinforcement learning agents relies on an adaptive mix of vector-based and transition-based strategies.PLoS biology · 2025Article
- Non-human primates can flexibly learn serial sequences and reorder context-dependent object sequences.PLoS biology · 2025Article
- Inferring neural population codes forProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories.eLife · 2025Article
- Prenatal protein malnutrition decreases neuron numbers in the parahippocampal region but not prefrontal cortex in adult rats.Nutritional neuroscience · 2025Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.eLife · 2025Article
- Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.bioRxiv : the preprint server for biology · 2024Article
- Transitional gradation and the distinction between episodic and semantic memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Interactions between neural representations of the social and spatial environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Forming cognitive maps for abstract spaces: the roles of the human hippocampus and orbitofrontal cortex.Communications biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Entorhinal cortical grid cells fire in a periodic pattern that tiles space, which is suggestive of a spatial coordinate system. However, irregularities in the grid pattern as well as responses of grid cells in contexts other than spatial navigation have presented a challenge to existing models of entorhinal function. In this Perspective, we propose that hippocampal input provides a key informative drive to the grid network in both spatial and non-spatial circumstances, particularly around salient events. We build on previous models in which neural activity propagates through the entorhinal-hippocampal network in time. This temporal contiguity in network activity points to temporal order as a necessary characteristic of representations generated by the hippocampal formation. We advocate that interactions in the entorhinal-hippocampal loop build a topological representation that is rooted in the temporal order of experience. In this way, the structure of grid cell firing supports a learned topology rather than a rigid coordinate frame that is bound to measurements of the physical world.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.