ReviewNature reviews. Cardiology2022
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing.
Review in Nature reviews. Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- One-Step Coordinated Multi-Kinetic 4D Printing of Human Vascularized Cardiac Tissues with Selective Fast-Shrinking Capillaries.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Cardiac repair and regeneration: cell therapy, in vivo reprogramming, and the promise of extracellular vesicles.Experimental & molecular medicine · 2025Review
- Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Remuscularizing the failing heart in primates.Nature reviews. Cardiology · 2025Article
- 3D-Printed Myocardium-Specific Structure Enhances Maturation and Therapeutic Efficacy of Engineered Heart Tissue in Myocardial Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bioprinted optoelectronically active cardiac tissues.Science advances · 2025Article
- Advances in cardiac organoid research: implications for cardiovascular disease treatment.Cardiovascular diabetology · 2025Review
- Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration.Smart medicine · 2024Article
- Progress in Organ Bioprinting for Regenerative Medicine.Engineering (Beijing, China) · 2024Article
- Progress of organoid platform in cardiovascular research.Bioactive materials · 2024Review
- Customizable Hydrogel Coating of ECM-Based Microtissues for Improved Cell Retention and Tissue Integrity.Gels (Basel, Switzerland) · 2024Article
- Applications of 3D Printing Technology in Diagnosis and Management of Heart Failure.Current treatment options in cardiovascular medicine · 2024Article
- Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques.Cell stem cell · 2024Article
- Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics.Journal of xenobiotics · 2024Review
- Engineered heart tissue: Design considerations and the state of the art.Biophysics reviews · 2024Review
- Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies.Materials today. Bio · 2024Review
- Development of 3D printed electrospun vascular graft loaded with tetramethylpyrazine for reducing thrombosis and restraining aneurysmal dilatation.Burns & trauma · 2024Article
- Virtual tissue microstructure reconstruction across species using generative deep learning.PloS one · 2024Article
- Construction of millimeter-scale vascularized engineered myocardial tissue using a mixed gel.Regenerative biomaterials · 2024Article
- Editorial: Constructing the vascular or cardiac tissue and organoids: the combination of biomedicine and engineering.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successfully engineering a functional, human, myocardial pump would represent a therapeutic alternative for the millions of patients with end-stage heart disease and provide an alternative to animal-based preclinical models. Although the field of cardiac tissue engineering has made tremendous advances, major challenges remain, which, if properly resolved, might allow the clinical implementation of engineered, functional, complex 3D structures in the future. In this Review, we provide an overview of state-of-the-art studies, challenges that have not yet been overcome and perspectives on cardiac tissue engineering. We begin with the most clinically relevant cell sources used in this field and discuss the use of topological, biophysical and metabolic stimuli to obtain mature phenotypes of cardiomyocytes, particularly in relation to organized cytoskeletal and contractile intracellular structures. We then move from the cellular level to engineering planar cardiac patches and discuss the need for proper vascularization and the main strategies for obtaining it. Finally, we provide an overview of several different approaches for the engineering of volumetric organs and organ parts - from whole-heart decellularization and recellularization to advanced 3D printing technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.